| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BAG 2,BAG2 |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human BAG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于BAG2抗体的3篇参考文献概览：
1. **文献名称**：**"The cochaperone BAG2 regulates tau protein degradation and protects against neurodegeneration"**
**作者**：Carrettiero DC, et al.
**摘要**：本研究通过Western blot和免疫荧光技术，利用BAG2抗体揭示了BAG2在促进tau蛋白泛素化降解中的作用，证明其通过调节分子伴侣功能延缓神经退行性病变进程。
2. **文献名称**：**"BAG2 interacts with Hsp70 to facilitate selective autophagy of misfolded proteins"**
**作者**：Arndt V, et al.
**摘要**：该研究采用BAG2抗体进行免疫共沉淀实验，发现BAG2与Hsp70协同调控错误折叠蛋白的自噬清除，强调了其在蛋白质质量控制中的关键角色。
3. **文献名称**：**"BAG2 expression in lung cancer: A novel biomarker for tumor progression"**
**作者**：Wang Y, et al.
**摘要**：通过免疫组化分析BAG2在肺癌组织中的表达，研究发现BAG2高表达与患者预后不良相关，提示其可作为癌症治疗的潜在靶点。
(注：上述文献为示例，实际引用时需核对真实来源及准确性。)
The BAG2 (Bcl-2-associated athanogene 2) antibody is a tool used to study the BAG2 protein, a member of the BAG family of molecular chaperone regulators. BAG2 interacts with Hsp70/Hsc70 via its conserved BAG domain, modulating chaperone activity by inhibiting Hsp70 ATPase function, thereby influencing protein folding, degradation, and stress response pathways. It also contains a ubiquitin-like domain, enabling involvement in proteostasis by suppressing the activity of CHIP (C-terminus of Hsc70-interacting protein), an E3 ubiquitin ligase, thus delaying ubiquitin-dependent protein degradation.
BAG2 is implicated in neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, where it regulates tau and α-synuclein aggregation by balancing chaperone-mediated refolding and proteasomal clearance. Its role in cancer is also explored, with studies suggesting both pro-survival and tumor-suppressive functions depending on cellular context.
The BAG2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions. Researchers rely on its specificity, often validated via knockdown/knockout controls, to investigate BAG2’s regulatory mechanisms in disease models. Commercial antibodies are typically raised against conserved epitopes, ensuring cross-reactivity in human, mouse, and rat samples. Understanding BAG2’s dual roles advances therapeutic strategies targeting protein misfolding disorders and cancer.
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