WB | 咨询技术 | Human,Mouse,Rat |
IF | 1/20-1/50 | Human,Mouse,Rat |
IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 1/20-1/100 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | 6-bisphosphatase; 6-P2ase 3; Fructose-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; uPFK 2;;PFKFB3 |
WB Predicted band size | 60 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | A synthesized peptide derived from human PFKFB3 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于PFKFB3抗体的参考文献摘要:
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1. **"The PFKFB3 inhibitor AZ-67 acts as a non-genetic chemosensitizer in human cancer"**
*Authors: Clem B., Telang S., Clem A., et al.*
摘要:研究报道了PFKFB3抑制剂AZ-67通过靶向肿瘤细胞糖酵解途径增强化疗敏感性,使用PFKFB3抗体验证了蛋白表达水平与药物响应的相关性,表明抑制PFKFB3可降低肿瘤细胞的糖酵解活性。
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2. **"Role of PFKFB3-driven glycolysis in vessel sprouting"**
*Authors: Schoors S., De Bock K., Cantelmo A.R., et al.*
摘要:通过PFKFB3抗体检测血管内皮细胞中蛋白表达,发现PFKFB3通过促进糖酵解调控内皮细胞迁移和血管生成,基因敲除或抗体阻断实验显示其抑制可减少病理性血管增生。
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3. **"6-Phosphofructo-2-kinase/fructose-2.6-bisphosphatase-3 is required for the energy balance of cancer cells"**
*Authors: Yalcin A., Telang S., Clem B., et al.*
摘要:研究利用PFKFB3抗体分析多种癌细胞系中的表达差异,证实PFKFB3通过调节果糖-2.6-二磷酸水平维持癌细胞的高糖酵解速率,是肿瘤能量代谢的关键调控因子。
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以上文献均通过PFKFB3抗体检测蛋白表达,探讨其在代谢调控及疾病治疗中的作用。如需具体卷期或页码,可进一步提供文献数据库检索信息。
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