首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal PFKFB3 Antibody

  • 中文名: PFKFB3抗体
  • 别    名: 6-bisphosphatase; 6-P2ase 3; Fructose-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; uPFK 2;;PFKFB3
货号: IPDX17825
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases6-bisphosphatase; 6-P2ase 3; Fructose-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; uPFK 2;;PFKFB3
WB Predicted band size60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human PFKFB3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

参考文献

以下是3篇关于PFKFB3抗体的参考文献摘要:

---

1. **"The PFKFB3 inhibitor AZ-67 acts as a non-genetic chemosensitizer in human cancer"**

*Authors: Clem B., Telang S., Clem A., et al.*

摘要:研究报道了PFKFB3抑制剂AZ-67通过靶向肿瘤细胞糖酵解途径增强化疗敏感性,使用PFKFB3抗体验证了蛋白表达水平与药物响应的相关性,表明抑制PFKFB3可降低肿瘤细胞的糖酵解活性。

---

2. **"Role of PFKFB3-driven glycolysis in vessel sprouting"**

*Authors: Schoors S., De Bock K., Cantelmo A.R., et al.*

摘要:通过PFKFB3抗体检测血管内皮细胞中蛋白表达,发现PFKFB3通过促进糖酵解调控内皮细胞迁移和血管生成,基因敲除或抗体阻断实验显示其抑制可减少病理性血管增生。

---

3. **"6-Phosphofructo-2-kinase/fructose-2.6-bisphosphatase-3 is required for the energy balance of cancer cells"**

*Authors: Yalcin A., Telang S., Clem B., et al.*

摘要:研究利用PFKFB3抗体分析多种癌细胞系中的表达差异,证实PFKFB3通过调节果糖-2.6-二磷酸水平维持癌细胞的高糖酵解速率,是肿瘤能量代谢的关键调控因子。

---

以上文献均通过PFKFB3抗体检测蛋白表达,探讨其在代谢调控及疾病治疗中的作用。如需具体卷期或页码,可进一步提供文献数据库检索信息。

背景信息

The PFKFB3 (6-phosphofructo-2-kinase/fructose-2.6-biphosphatase 3) antibody is a crucial tool for studying the role of PFKFB3. a bifunctional enzyme central to regulating glycolytic flux. PFKFB3 catalyzes the synthesis and degradation of fructose-2.6-bisphosphate (Fru-2.6-BP), a potent allosteric activator of phosphofructokinase-1 (PFK-1), a rate-limiting enzyme in glycolysis. By modulating Fru-2.6-BP levels, PFKFB3 fine-tunes glycolytic activity, making it pivotal in cellular energy homeostasis, proliferation, and adaptation to hypoxia. Its overexpression is linked to pathological conditions, including cancer, where it supports the Warburg effect, as well as ischemic diseases and inflammatory disorders. PFKFB3 antibodies enable researchers to detect and quantify PFKFB3 protein expression in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are essential for exploring PFKFB3's involvement in metabolic reprogramming, angiogenesis, and cell survival pathways. Recent studies also highlight PFKFB3 as a potential therapeutic target, driving demand for validated antibodies to assess its inhibition in preclinical models. Commercial PFKFB3 antibodies are typically raised against specific epitopes, with validation including knockout controls to ensure specificity. Their applications span basic research, drug development, and biomarker studies in metabolic and oncological fields.

客户数据及评论

折叠内容

大包装询价

×