| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cb486; Mybbp1a; P160; p160MBP; p67MBP; PAP2; RP23 48A2.3;;Myb binding protein 1A |
| WB Predicted band size | 149 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Myb binding protein 1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MYBBP1A抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **标题**: "MYBBP1A regulates ribosomal RNA transcription through interaction with c-Myc"
**作者**: Smith J, et al.
**摘要**: 本研究利用MYBBP1A抗体进行免疫共沉淀实验，发现MYBBP1A通过与c-Myc蛋白相互作用调控核糖体RNA的转录，揭示了其在细胞增殖中的关键作用。
2. **标题**: "Nuclear localization and stress-induced phosphorylation of MYBBP1A in cancer cells"
**作者**: Chen L, et al.
**摘要**: 通过免疫荧光和Western blot技术结合MYBBP1A抗体，证实MYBBP1A在多种癌细胞系中定位于核仁，并在氧化应激条件下发生磷酸化修饰，提示其参与肿瘤应激响应通路。
3. **标题**: "MYBBP1A as a novel biomarker in breast cancer progression"
**作者**: Wang Y, et al.
**摘要**: 使用MYBBP1A抗体对乳腺癌组织样本进行免疫组化分析，发现其高表达与肿瘤侵袭性呈正相关，表明MYBBP1A可能作为乳腺癌预后的潜在标志物。
4. **标题**: "Functional analysis of MYBBP1A in embryonic development using knockout models"
**作者**: Gonzalez R, et al.
**摘要**: 通过MYBBP1A抗体检测基因敲除小鼠模型中的蛋白表达缺失，发现MYBBP1A缺失导致胚胎发育异常，强调了其在早期发育中的必要性。
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*注：以上文献为模拟内容，实际研究中建议通过PubMed、Google Scholar等平台检索真实文献。*
MYBBP1A (MYB-binding protein 1A) is a nucleolar protein implicated in diverse cellular processes, including ribosomal RNA (rRNA) synthesis, cell cycle regulation, and transcriptional control. It was initially identified as a binding partner of the MYB proto-oncogene family, which regulates cell proliferation and differentiation. Structurally, MYBBP1A contains coiled-coil domains that facilitate interactions with multiple proteins, such as p53. NF-κB, and components of the RNA polymerase I complex. Functionally, it acts as a tumor suppressor by modulating p53 activity, enhancing its stability and transcriptional output under stress conditions. MYBBP1A also participates in nucleolar stress responses, relocating from nucleoli to the nucleoplasm during stress to activate p53-dependent apoptosis or cell cycle arrest.
Antibodies targeting MYBBP1A are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its role in cancer biology, ribosomal biogenesis, and stress signaling pathways. Aberrant MYBBP1A expression has been linked to tumor progression, chemoresistance, and neurodegenerative disorders, making these antibodies valuable for both basic research and clinical diagnostics. Validated antibodies specifically recognize distinct epitopes or post-translational modifications, aiding in mechanistic studies of MYBBP1A's regulatory networks. Overall, MYBBP1A antibodies provide critical insights into its dual roles as a nucleolar organizer and stress-responsive tumor suppressor.
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