| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | hP1.A; HP1A; HPS2; pNR2; pS2; TFF1;;Trefoil factor 1 |
| WB Predicted band size | 9 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Trefoil factor 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于Estrogen-Inducible Protein pS2(TFF1)抗体的参考文献摘要概括：
1. **文献名称**: *"TFF1/pS2 overexpression in gastric carcinogenesis: clinical and pathologic correlations"*
**作者**: Rio MC 等
**摘要**: 研究使用pS2抗体通过免疫组化分析胃癌组织中TFF1表达，发现其过表达与肠型胃癌发生相关，且受雌激素受体信号通路调控。
2. **文献名称**: *"Estrogen regulation of pS2 gene expression in breast cancer cells"*
**作者**: Brown AM 等
**摘要**: 通过Western blot和免疫荧光技术，验证pS2抗体特异性，证实雌激素通过ERα途径诱导乳腺癌细胞中pS2蛋白表达，该蛋白可作为雌激素活性标志物。
3. **文献名称**: *"Utility of pS2 immunohistochemistry in breast cancer prognosis"*
**作者**: Foekens JA 等
**摘要**: 采用pS2单克隆抗体对乳腺癌组织进行染色，发现pS2阳性患者对内分泌治疗反应更佳，提示其作为预后生物标志物的潜力。
(注：以上文献信息为模拟概括，实际引用建议通过PubMed或Google Scholar以关键词"pS2 antibody/TFF1 antibody"检索最新文献。)
The estrogen-inducible protein pS2. also known as Trefoil Factor 1 (TFF1), is a small secretory protein encoded by the TFF1 gene. Discovered in the 1980s, pS2 was initially identified as a gene transcriptionally activated by estrogen in hormone-responsive breast cancer cells. It belongs to the trefoil factor family, characterized by a conserved three-loop structure critical for mucosal protection and repair in epithelial tissues. pS2 is primarily expressed in the gastrointestinal tract, particularly in gastric mucosa, and plays roles in maintaining mucosal integrity, promoting cell migration, and suppressing inflammation.
Antibodies targeting pS2 are widely used in research to investigate its expression patterns, regulatory mechanisms, and clinical relevance. pS2 overexpression is associated with estrogen receptor (ER)-positive breast cancers, where it serves as a marker of estrogen signaling activity. Its expression is also linked to certain gastric pathologies, including cancer. In diagnostics, pS2 antibodies aid in immunohistochemical (IHC) detection to assess tumor hormone responsiveness or classify subtypes. Studies further explore pS2's dual role as both a tumor suppressor and potential oncogenic factor, depending on context. Researchers utilize these antibodies in techniques like Western blotting, ELISA, and immunofluorescence to unravel pS2's biological functions and therapeutic implications in cancer and mucosal diseases.
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