| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ANF; ANP; PND; ATFB6; CDD-ANF; NPPA; Natriuretic peptides A; LANP; VSDL;;Natriuretic peptides A |
| WB Predicted band size | Calculated MW: 16 kDa ; Observed MW: 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Natriuretic peptides A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ANP(心房钠尿肽)抗体的3篇示例参考文献(注：以下为虚构示例，实际文献请通过学术数据库查询)：
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1. **文献名称**：*Autoantibodies Against Atrial Natriuretic Peptide in Heart Failure: Pathological Implications*
**作者**：Smith J, et al.
**摘要**：研究揭示了心力衰竭患者血清中抗ANP自身抗体的存在，发现其可能通过干扰ANP的清除导致循环ANP水平升高，从而加重心脏负荷和纤维化。
2. **文献名称**：*Anti-ANP Antibodies as a Novel Biomarker in Hypertensive Disorders*
**作者**：Johnson R, et al.
**摘要**：探讨了高血压患者中抗ANP抗体的流行率及其与左心室肥厚的相关性，提示此类抗体可能通过拮抗ANP的降压作用参与疾病进展。
3. **文献名称**：*ANP Autoantibodies in Autoimmune Diseases: Association with Systemic Lupus Erythematosus*
**作者**：Lee S, et al.
**摘要**：首次报道系统性红斑狼疮(SLE)患者中抗ANP抗体的高表达，并发现其与患者心血管并发症风险增加相关，提示自身免疫交叉反应的可能机制。
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如需真实文献，建议在PubMed或Google Scholar中搜索关键词："ANP autoantibodies"、"anti-ANP antibodies"、"atrial natriuretic peptide autoimmunity"。
Atrial natriuretic peptide (ANP) antibodies are immunological tools used to detect and quantify ANP, a cardiac hormone primarily secreted by atrial cardiomyocytes in response to stretching of the atrial walls. ANP plays a critical role in regulating blood pressure, fluid balance, and sodium excretion by promoting vasodilation, diuresis, and inhibition of the renin-angiotensin-aldosterone system. Research on ANP antibodies emerged alongside discoveries of ANP's physiological roles in the 1980s, driven by the need to understand its involvement in cardiovascular and renal diseases.
These antibodies are typically developed in laboratory animals (e.g., rabbits, mice) using synthetic ANP fragments as antigens. They enable precise detection methods like ELISA, radioimmunoassay, and immunohistochemistry, facilitating studies on ANP expression, secretion patterns, and receptor interactions. Clinically, ANP antibodies aid in diagnosing heart failure and hypertension by measuring circulating ANP levels, which often correlate with disease severity.
Recent applications extend to exploring ANP's anti-inflammatory and metabolic effects, including its role in obesity and diabetes. Challenges remain in ensuring antibody specificity due to structural similarities between ANP and related natriuretic peptides (BNP, CNP). Ongoing research focuses on refining antibody-based assays and therapeutic strategies targeting ANP pathways.
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