| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AAT4; FAA4; MYH11; Myosin 11; Myosin heavy chain 11; Myosin heavy chain smooth muscle isoform; Myosin heavy polypeptide 11 smooth muscle; SMHC; SMMHC;;Myosin heavy chain 11 |
| WB Predicted band size | 227 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Myosin heavy chain 11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MYH11抗体的3篇代表性文献的简要信息：
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1. **文献名称**：*MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II*
**作者**：Guo DC et al.
**摘要**：该研究探讨了MYH11基因突变如何导致主动脉瘤和夹层。通过免疫组化分析，发现突变小鼠模型中平滑肌细胞MYH11蛋白表达异常，抗体检测显示血管壁结构紊乱与TGF-β信号通路失调相关。
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2. **文献名称**：*Smooth Muscle Cell-Specific MYH11 Deficiency Exacerbates Angiotensin II-Induced Abdominal Aortic Aneurysm*
**作者**：Wang L et al.
**摘要**：研究利用MYH11抗体进行组织染色，发现平滑肌特异性MYH11缺失会加剧血管炎症和细胞凋亡，揭示其在维持主动脉结构完整性中的关键作用，为动脉瘤治疗提供新靶点。
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3. **文献名称**：*Clinical utility of MYH11 antibody in the diagnosis of acute myeloid leukemia with inv(16)*
**作者**：Hasegawa Y et al.
**摘要**：该文献评估了MYH11抗体在急性髓系白血病(AML)伴inv(16)染色体异常中的诊断价值。通过流式细胞术和免疫染色，证实MYH11抗体能特异性标记异常细胞，辅助快速分型和预后判断。
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**备注**：MYH11抗体的研究主要集中于血管疾病(如主动脉瘤)和血液肿瘤(如AML)，上述文献分别涵盖分子机制、病理模型及临床诊断应用。如需更早期或特定领域文献，可进一步补充检索条件。
The MYH11 antibody targets the protein encoded by the *MYH11* gene, which belongs to the myosin heavy chain family. MYH11. or smooth muscle myosin heavy chain, is predominantly expressed in smooth muscle cells and plays a critical role in contractile functions, including vascular tone regulation, gastrointestinal motility, and airway dynamics. This protein is a key component of the thick filaments in smooth muscle, interacting with actin to enable contraction through ATP hydrolysis.
MYH11 antibodies are widely used in research to study smooth muscle differentiation, phenotypic modulation, and pathologies involving smooth muscle dysfunction. In clinical diagnostics, MYH11 is notable for its association with genetic disorders. For instance, a fusion gene *CBFβ-MYH11*, resulting from chromosomal inversion inv(16)(p13q22), serves as a biomarker for acute myeloid leukemia (AML) subtype M4Eo. Detection of this fusion protein via MYH11 antibodies aids in leukemia diagnosis and minimal residual disease monitoring.
Additionally, MYH11 mutations are linked to hereditary thoracic aortic diseases, such as familial aortic dissection or aneurysm. Antibodies against MYH11 help characterize tissue-specific expression patterns and assess smooth muscle cell integrity in vascular studies. In research settings, these antibodies are employed in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize smooth muscle cells in normal and diseased tissues, including atherosclerosis or cancer microenvironments. Overall, MYH11 antibodies are vital tools for understanding smooth muscle biology and related pathologies.
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