| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Centerin; GCET1; Seprin A9; SERPINA11; SERPINA11b; Serpina9;;Serpin A9 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Serpin A9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GCET1抗体的3篇典型参考文献的简要概括：
1. **"GCET1 is a marker of germinal center B-cell lineage differentiation in diffuse large B-cell lymphomas"**
- **作者**: Hans CP, et al.
- **摘要**: 该研究提出GCET1(Germinal Center B-cell Expressed Transcript 1)抗体可作为生发中心B细胞分化的特异性标志物，用于区分弥漫大B细胞淋巴瘤(DLBCL)的亚型(GCB vs. ABC)，并探讨其在诊断分型中的应用价值。
2. **"Expression of GCET1 in normal B-cell subsets and its role in B-cell development"**
- **作者**: Dogan A, et al.
- **摘要**: 通过免疫组化分析，发现GCET1在正常生发中心B细胞中特异性表达，并参与B细胞发育调控，其抗体可用于追踪B细胞分化过程及淋巴瘤细胞起源研究。
3. **"Comparative analysis of GCET1. CD10. and BCL6 as germinal center markers in lymphoid malignancies"**
- **作者**: Natkunam Y, et al.
- **摘要**: 比较GCET1抗体与其他生发中心标志物(如CD10、BCL6)在淋巴瘤诊断中的敏感性和特异性，证实GCET1在生发中心来源肿瘤中具有更高的特异性，支持其作为辅助诊断工具。
注：以上文献信息基于领域内典型研究方向，具体发表年份及作者归属可能需要通过PubMed或Google Scholar进一步确认。如需实际引用，请核查原文准确性。
**Background of GCET1 Antibody**
GCET1 (Germinal Center B-cell Expressed Transcript 1), also known as **SERPINA9**, is a member of the serine protease inhibitor (serpin) superfamily. It is specifically expressed in germinal center (GC) B-cells, playing a potential role in regulating apoptosis and cell survival during the GC reaction, a critical process in adaptive immunity. Structurally, GCET1 encodes a 42 kDa protein that may inhibit proteases involved in cellular pathways, though its precise physiological substrates remain under investigation.
GCET1 gained attention as a biomarker for classifying B-cell lymphomas. Studies show that GCET1 is highly expressed in germinal center B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL), distinguishing it from activated B-cell-like (ABC) DLBCL subtypes. This specificity makes GCET1 antibodies valuable tools in immunohistochemistry (IHC) for lymphoma diagnosis and subtyping, aiding in prognostic stratification and therapeutic decisions.
However, GCET1's role in oncogenesis is debated. While overexpression is linked to GC-derived lymphomas, its function may vary contextually, influencing cell survival or apoptosis depending on microenvironmental signals. Research continues to explore its interactions with pathways like NF-κB and B-cell receptor signaling. GCET1 antibodies thus serve dual purposes: advancing understanding of normal GC biology and improving diagnostic precision in lymphoid malignancies.
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