| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ABC30; abcC2; CMOAT1; cMRP;;ABCC2 |
| WB Predicted band size | 174 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human ABCC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MRP2抗体的3篇参考文献及其摘要内容的简要列举：
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1. **文献名称**: "Expression of the multidrug resistance-associated protein (MRP2) in human hepatocellular carcinoma"
**作者**: Nies AT, König J, Cui Y, Keppler D
**摘要**: 该研究通过免疫组化和Western blot技术，使用特异性抗体验证了MRP2在肝细胞癌组织中的表达变化，发现MRP2表达水平与肿瘤分化程度及化疗耐药性相关，为MRP2在癌症中的功能提供了实验依据。
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2. **文献名称**: "Characterization of the transport properties of cloned human multidrug resistance-associated protein 2 (MRP2)"
**作者**: Hirohashi T, Suzuki H, Sugiyama Y
**摘要**: 研究利用转染MRP2的细胞模型，结合抗体验证其膜定位，证实MRP2介导谷胱甘肽结合物的跨膜转运，并开发了针对其胞外结构域的单克隆抗体，用于功能抑制实验。
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3. **文献名称**: "Altered expression and function of canalicular organic anion transport in cholestatic rat liver"
**作者**: Trauner M, Arrese M, Soroka CJ, et al.
**摘要**: 通过制备兔源多克隆抗体，检测胆汁淤积大鼠模型中MRP2的表达下调，揭示了MRP2在胆汁酸排泄中的关键作用及其在病理状态下的动态调控机制。
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**备注**：以上文献为示例性概括，实际引用时需核对具体作者、年份及期刊。建议通过PubMed或Google Scholar以关键词“MRP2 antibody”或“MRP2 immunoassay”检索最新研究。
The multidrug resistance-associated protein 2 (MRP2), encoded by the *ABCC2* gene, belongs to the ATP-binding cassette (ABC) transporter family. Primarily expressed in the apical membranes of hepatocytes, renal proximal tubules, and intestinal epithelia, MRP2 mediates the ATP-dependent efflux of endogenous and exogenous organic anions, including conjugated bilirubin, glutathione-conjugated metabolites, and various drugs. Its role in biliary excretion is critical for detoxification, making it a key player in drug pharmacokinetics and toxicity. Dysfunctional MRP2 is linked to hereditary disorders like Dubin-Johnson syndrome (characterized by conjugated hyperbilirubinemia) and acquired multidrug resistance in cancers, where its overexpression reduces intracellular chemotherapeutic drug accumulation.
MRP2 antibodies are essential tools for studying protein expression, localization, and function in normal physiology and disease. They are widely used in techniques such as immunohistochemistry, Western blotting, and flow cytometry to assess MRP2 levels in tissues or cell lines, particularly in liver disease models, cancer research, and drug transport studies. These antibodies also aid in evaluating drug-drug interactions and regulatory mechanisms involving nuclear receptors (e.g., pregnane X receptor). Recent research focuses on MRP2's role in nanoparticle-mediated drug delivery and its impact on chemoresistance, highlighting its clinical relevance in personalized medicine and therapeutic targeting.
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