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Rabbit Monoclonal Drebrin Antibody

  • 中文名: Drebrin抗体
  • 别    名: D0S117E; DBN1; Drebrin 1; Drebrin; Drebrin E2; Drebrin1; DrebrinE; ;Drebrin
货号: IPDX17605
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesD0S117E; DBN1; Drebrin 1; Drebrin; Drebrin E2; Drebrin1; DrebrinE; ;Drebrin
WB Predicted band sizeCalculated MW: 71 kDa ; Observed MW: 120 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Drebrin
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于Drebrin抗体的参考文献及其摘要概括:

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1. **"Drebrin, a dendritic spine protein, is altered in Alzheimer’s disease"**

*Authors: Harigaya Y, Shoji M, Hirai S*

摘要:研究通过免疫组织化学和Western blot分析,发现阿尔茨海默病患者脑组织中Drebrin表达显著降低,提示其与突触功能障碍相关。

2. **"Monoclonal antibodies against drebrin: Characterization and application"**

*Authors: Shirao T, Kojima N, Obata K*

摘要:首次报道了针对Drebrin的单克隆抗体制备,验证了其在免疫印迹和免疫荧光中的特异性,并用于研究神经元发育中的Drebrin动态分布。

3. **"Role of drebrin in the reorganization of actin cytoskeleton in neuronal growth cones"**

*Authors: Mizui T, Takahashi H, Sekino Y, Shirao T*

摘要:利用Drebrin抗体阻断实验,证明Drebrin通过调节肌动蛋白细胞骨架影响轴突生长锥的形态和运动能力。

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以上文献聚焦于Drebrin抗体的开发应用及其在神经生物学研究中的作用,涵盖疾病机制、抗体特性及细胞功能研究。

背景信息

Drebrin antibodies are essential tools in neuroscience and cell biology research, targeting drebrin, a cytoskeletal protein crucial for regulating actin dynamics. Drebrin exists in two major isoforms (E and A), with the embryonic form (E) prevalent during development and the adult form (A) enriched in mature neurons, particularly in dendritic spines. It plays a key role in synapse formation, plasticity, and stability by binding to F-actin and modulating its organization. Dysregulation of drebrin is linked to neurological disorders, including Alzheimer’s disease (AD), where reduced drebrin levels correlate with synaptic loss and cognitive decline.

Antibodies against drebrin enable researchers to study its expression, localization, and interactions via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These antibodies help visualize drebrin’s redistribution during synaptic activity or pathological changes in disease models. For example, in AD research, drebrin antibodies are used to investigate its interaction with amyloid-beta plaques and tau pathology. Commercially available drebrin antibodies are typically validated for specificity across species (e.g., human, mouse, rat) and applications, though isoform-specific antibodies are prioritized to distinguish functional roles. Recent studies also explore drebrin’s potential role in cancer cell migration via epithelial-mesenchymal transition (EMT), expanding its relevance beyond neuroscience. Ensuring antibody validation through knockout controls remains critical to avoid off-target artifacts in experimental outcomes.

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