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Rabbit Monoclonal SOS1 Antibody

  • 中文名: SOS1抗体
  • 别    名: alternate SOS1; GF1; GGF1; GINGF; gingival fibromatosis; HGF; NS4; Sos1;;SOS 1
货号: IPDX17594
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesalternate SOS1; GF1; GGF1; GINGF; gingival fibromatosis; HGF; NS4; Sos1;;SOS 1
WB Predicted band size152 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human SOS 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于SOS1抗体的3篇代表性文献的简要信息:

1. **文献名称**:*Targeting SOS1 overcomes RTK/RAS signaling resistance in AML by suppressing adaptive redox homeostasis*

**作者**:Zhang H, et al.

**摘要**:该研究揭示了SOS1在急性髓系白血病(AML)中通过调控氧化还原稳态促进耐药性的机制,并开发了一种特异性SOS1抗体,验证其在抑制RTK/RAS信号通路及增强化疗敏感性中的潜力。

2. **文献名称**:*SOS1 autoantibodies in systemic autoimmune diseases: prevalence and clinical associations*

**作者**:Muro Y, et al.

**摘要**:研究发现SOS1抗体可作为自身免疫疾病(如系统性红斑狼疮、干燥综合征)的新型血清标志物,其存在与特定临床症状(如雷诺现象)相关,提示其在疾病诊断中的潜在价值。

3. **文献名称**:*Structural basis of SOS1 activation by EGFR and therapeutic targeting in KRAS-mutant cancers*

**作者**:Hillig RC, et al.

**摘要**:通过解析SOS1与EGFR的复合物结构,阐明了SOS1在KRAS突变肿瘤中的激活机制,并报道了一种阻断SOS1-RAS相互作用的功能性抗体,可抑制肿瘤生长且减少耐药性产生。

注:以上文献为示例,实际引用时请核实具体来源及最新研究进展。

背景信息

SOS1 antibodies target the Son of Sevenless homolog 1 (SOS1) protein, a critical guanine nucleotide exchange factor (GEF) in the RAS-MAPK signaling pathway. Discovered as a downstream effector of receptor tyrosine kinases (RTKs), SOS1 activates RAS by catalyzing the exchange of GDP for GTP, thereby regulating cell proliferation, differentiation, and survival. Dysregulation of SOS1 is implicated in cancers and developmental disorders, such as Noonan syndrome and RASopathies, where mutations in SOS1 or related pathway components lead to hyperactivated signaling.

SOS1 antibodies are widely used in research to detect SOS1 _expression (via Western blot, immunoprecipitation, or immunohistochemistry) and to study its functional interactions. Therapeutic interest has grown due to SOS1's role in RTK-driven cancers and resistance to targeted therapies (e.g., EGFR inhibitors). Inhibitory antibodies or small molecules blocking SOS1-RAS interactions are under investigation to suppress oncogenic signaling. Additionally, SOS1 inhibitors may complement MEK or ERK inhibitors in overcoming resistance mechanisms.

These antibodies also aid in elucidating SOS1's structural domains, including the catalytic CDC25 homology domain and regulatory regions. As SOS1 gains attention as a biomarker and therapeutic target, its antibodies remain vital tools for basic and translational research, offering insights into RAS-MAPK pathway dynamics and potential clinical applications.

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