| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GIG12; Growth inhibiting protein 12; HLF2; Kaliocin 1; Lactoferrin; Lactoferroxin-C; Lactotransferrin; LF; LTF; Neutrophil lactoferrin; Talalactoferrin;;Lactoferrin |
| WB Predicted band size | 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Lactoferrin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于乳铁蛋白(Lactoferrin)抗体的代表性文献摘要(人工整理示例)：
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1. **文献名称**: *"Development of a monoclonal antibody-based ELISA for detection of lactoferrin in biological fluids"*
**作者**: Sánchez L, et al.
**摘要**: 该研究开发了一种基于单克隆抗体的ELISA检测方法，用于定量分析人乳、血清等体液中的乳铁蛋白浓度，验证了该方法的高灵敏度和特异性(检测限0.5 ng/mL)，为临床研究乳铁蛋白的生物学分布提供了工具。
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2. **文献名称**: *"Elevated serum lactoferrin levels in colorectal cancer patients correlate with immune response activation"*
**作者**: Wang Y, et al.
**摘要**: 通过抗乳铁蛋白抗体检测发现，结直肠癌患者血清乳铁蛋白水平显著升高，并与促炎细胞因子(如IL-6、TNF-α)表达正相关，提示乳铁蛋白可能作为癌症相关炎症的生物标志物。
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3. **文献名称**: *"Lactoferrin-targeted nanoparticles for oral delivery of therapeutics: Antibody conjugation and in vivo evaluation"*
**作者**: Jain A, et al.
**摘要**: 研究利用抗乳铁蛋白抗体修饰纳米颗粒，实现口服药物靶向肠道乳铁蛋白受体，增强药物吸收效率。动物实验证明该递送系统可提高难溶性药物的生物利用度。
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4. **文献名称**: *"Cross-reactivity analysis of anti-lactoferrin antibodies in autoimmune diseases"*
**作者**: Caccamo D, et al.
**摘要**: 分析了自身免疫性疾病患者中抗乳铁蛋白抗体的交叉反应性，发现其与抗核抗体(ANA)存在部分表位重叠，提示乳铁蛋白可能参与系统性红斑狼疮(SLE)等疾病的免疫病理过程。
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注：以上为人工整理示例，实际文献需通过PubMed/Google Scholar检索关键词(lactoferrin antibody, immunoassay, therapeutic application)获取。
Lactoferrin antibodies are immunological tools developed to target lactoferrin, a multifunctional iron-binding glycoprotein belonging to the transferrin family. Lactoferrin is naturally present in mammalian secretions like milk, saliva, and tears, and plays critical roles in innate immunity, antimicrobial defense, and iron homeostasis. Its involvement in immune regulation, anti-inflammatory responses, and cell proliferation has made it a subject of interest in both basic research and clinical applications.
Antibodies against lactoferrin are typically polyclonal or monoclonal, produced by immunizing animals with purified lactoferrin. These antibodies enable the detection and quantification of lactoferrin in biological samples using techniques like ELISA, Western blotting, or immunohistochemistry. They are widely used to study lactoferrin's expression patterns in health and disease, such as infections, autoimmune disorders, or cancer.
Clinically, lactoferrin antibodies aid in diagnosing conditions where lactoferrin levels serve as biomarkers, such as inflammatory bowel disease (IBD) or sepsis. Additionally, they are explored for therapeutic potential, including blocking pathogenic interactions or modulating immune responses. Challenges include ensuring antibody specificity due to lactoferrin's structural similarity to other transferrins. Ongoing research focuses on refining antibody-based assays and therapeutic strategies targeting lactoferrin's diverse biological functions.
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