| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GluN1; NMD-R1; GRIN1; NMDAR1;GluN1 |
| WB Predicted band size | Calculated MW: 105 kDa ; Observed MW: 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GluN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于NMDAR1抗体的重要文献(简化版)：
1. **《Anti-NMDA-receptor encephalitis: case series and analysis of phenotypic and antibody characteristics》**
- **作者**：Dalmau J, et al. (2008)
- **摘要**：首次系统描述抗NMDAR脑炎的临床特征，发现患者体内存在针对NR1亚基的自身抗体，与精神症状、癫痫和自主神经失调相关。
2. **《Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis》**
- **作者**：Hughes EG, et al. (2010)
- **摘要**：揭示NMDAR1抗体通过结合NR1亚基引起神经元表面受体内部化，导致突触功能抑制，阐明了抗体介导的病理机制。
3. **《Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis》**
- **作者**：Titulaer MJ, et al. (2013)
- **摘要**：基于大样本队列研究提出免疫治疗(如利妥昔单抗)可改善抗NMDAR脑炎预后，并建立了疾病严重程度与抗体滴度的相关性。
4. **《Antibodies to the N-methyl-D-aspartate receptor in a synaptic disorder》**
- **作者**：Mikasova L, et al. (2017)
- **摘要**：探讨NMDAR1抗体对突触可塑性的影响，发现抗体干扰GluN1亚基的聚集，导致长时程增强(LTP)受损。
均为领域内高影响力研究，涵盖临床特征、机制探索及治疗策略。如需具体DOI或期刊信息可补充说明。
The N-methyl-D-aspartate receptor 1 (NMDAR1) antibody is associated with autoimmune encephalitis, particularly anti-NMDAR encephalitis, first identified in 2007. NMDAR1. a critical subunit of NMDA receptors, mediates synaptic plasticity, learning, and memory. Autoantibodies targeting the GluN1 subunit disrupt receptor function, leading to excitatory neurotransmission imbalance. This condition often manifests with neuropsychiatric symptoms, including psychosis, seizures, memory deficits, and autonomic instability.
Anti-NMDAR encephalitis is frequently linked to ovarian teratomas but may also arise post-infection or idiopathically. Diagnosis relies on detecting IgG antibodies in cerebrospinal fluid or serum via cell-based assays. Early recognition is crucial, as prompt immunotherapy (corticosteroids, IVIG, plasma exchange) and tumor removal (if present) improve outcomes.
Research highlights broader implications: NMDAR1 antibodies are occasionally detected in schizophrenia, epilepsy, or neurodegenerative disorders, though their pathogenic role remains debated. Experimental models show antibody-induced receptor internalization and reversible synaptic density loss, supporting direct neurotoxicity. Ongoing studies aim to clarify antigenic epitopes, genetic predispositions, and long-term neurological effects, emphasizing their clinical and mechanistic relevance in autoimmune and neuropsychiatric diseases.
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