| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cas1; CAT; Catalase; Cs1;;Catalase |
| WB Predicted band size | 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Catalase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于过氧化氢酶(Catalase)抗体的参考文献示例(注：文献为虚构示例，仅用于展示格式，实际引用请查询真实数据库)：
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1. **文献名称**：*Catalase overexpression extends lifespan in transgenic mice*
**作者**：Schriner SE, et al.
**摘要**：本研究通过Western blot和免疫组化技术，使用特异性抗Catalase抗体检测转基因小鼠肝脏和脑组织中的过氧化氢酶表达，发现其过表达可显著减少氧化损伤并延长寿命(Science, 2005)。
2. **文献名称**：*Role of Catalase in Alzheimer's disease: Antibody-based detection in neuronal models*
**作者**：Chen Y, et al.
**摘要**：通过商业抗Catalase抗体(Abcam, Cat# ab12345)分析阿尔茨海默病模型小鼠的脑组织，发现Catalase活性下降与β-淀粉样蛋白诱导的氧化应激相关(Journal of Neuroscience, 2012)。
3. **文献名称**：*Antioxidant enzyme expression in breast cancer: Validation of Catalase-specific monoclonal antibodies*
**作者**：Smith JL, et al.
**摘要**：开发并验证了一种高特异性抗人Catalase单克隆抗体(克隆号CAT-3G10)，用于免疫荧光和流式细胞术，揭示乳腺癌细胞中Catalase表达与化疗耐药性负相关(Cancer Research, 2016)。
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如需真实文献，建议在PubMed或Google Scholar检索关键词："Catalase antibody application"、"Catalase immunohistochemistry"或结合具体研究领域(如疾病模型)。
Catalase antibodies are immunological tools designed to detect and study the enzyme catalase, a critical antioxidant protein found in nearly all aerobic organisms. Catalase plays a vital role in cellular defense by catalyzing the decomposition of hydrogen peroxide (H₂O₂) into water and oxygen, thereby mitigating oxidative stress and protecting cells from reactive oxygen species (ROS)-induced damage. Dysregulation of catalase activity or expression is linked to various pathologies, including neurodegenerative diseases, diabetes, cancer, and aging-related disorders.
These antibodies are widely used in research applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assays (ELISA) to quantify catalase levels, assess its localization in tissues or cells, and investigate its role in oxidative stress pathways. Catalase antibodies are often produced in host species like rabbits, mice, or goats, targeting specific epitopes of the enzyme. Monoclonal antibodies offer high specificity, while polyclonal antibodies provide broader epitope recognition.
Commercial catalase antibodies are typically validated for cross-reactivity across species, including human, mouse, rat, and others, ensuring versatility in experimental models. Their use has advanced understanding of redox biology, disease mechanisms, and therapeutic strategies targeting oxidative damage. Researchers also employ catalase antibodies to explore correlations between catalase deficiency and disease progression, aiding in biomarker discovery and drug development.
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