| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FABP1; FABPL; Fatty acid binding protein 1 liver; L FABP;;FABP1 |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human FABP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于FABP1抗体的3篇参考文献示例(虚构内容，仅作格式参考)：
1. **文献名称**：*"FABP1 as a Biomarker for Intestinal Injury: Validation of a Novel Monoclonal Antibody in Clinical Samples"*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种高特异性抗FABP1单克隆抗体，用于检测血清中FABP1水平，证实其在急性肠缺血和炎症性肠病中的诊断价值。
2. **文献名称**：*"Immunohistochemical Analysis of FABP1 in Hepatocellular Carcinoma: Correlation with Tumor Progression"*
**作者**：Li Y, et al.
**摘要**：通过免疫组化技术结合FABP1多克隆抗体，发现FABP1在肝癌组织中的低表达与患者预后不良显著相关，提示其作为治疗靶点的潜力。
3. **文献名称**：*"Comparative Evaluation of Commercial FABP1 Antibodies for Western Blot Sensitivity and Specificity"*
**作者**：Johnson R, et al.
**摘要**：系统评估了5种市售FABP1抗体在肝和小肠组织中的性能，确定了抗体批次间差异对实验可重复性的影响，并提出标准化使用建议。
4. **文献名称**：*"FABP1 Knockout Mice Reveal Altered Lipid Metabolism via Antibody-Based Proteomic Screening"*
**作者**：Wang H, et al.
**摘要**：利用FABP1特异性抗体进行蛋白质组学分析，发现FABP1缺失小鼠出现肝脏脂质代谢紊乱，阐明其在脂质转运中的核心作用。
(注：以上文献为模拟生成，实际引用需查询PubMed、Google Scholar等数据库获取真实文献。)
**Background of FABP1 Antibody**
Fatty Acid-Binding Protein 1 (FABP1), also known as liver-type FABP (L-FABP), is a small cytoplasmic protein (~14-15 kDa) primarily expressed in hepatocytes and intestinal epithelial cells. It plays a critical role in intracellular fatty acid transport, metabolism, and signaling by binding hydrophobic ligands such as long-chain fatty acids, eicosanoids, and bile acids. FABP1 is implicated in lipid homeostasis, inflammation modulation, and cellular stress responses.
FABP1 antibodies are immunological tools designed to detect and quantify FABP1 expression in tissues or biological fluids. These antibodies are widely used in research to study FABP1's involvement in metabolic disorders (e.g., obesity, diabetes), liver diseases (e.g., steatosis, hepatitis), and intestinal pathologies (e.g., inflammatory bowel disease). They enable techniques like immunohistochemistry (IHC), Western blotting, and ELISA to visualize tissue-specific distribution, assess protein levels, or evaluate diagnostic potential.
Elevated FABP1 levels in serum or urine are proposed biomarkers for organ damage, particularly in liver injury or intestinal ischemia. Additionally, FABP1 antibodies aid in exploring its role in cancer progression, as aberrant expression is observed in hepatocellular carcinoma and colorectal cancer. Their specificity and sensitivity make them vital for both basic research and clinical applications.
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