| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Urokinase-type plasminogen activator; U-plasminogen activator; Upa; PLAU; ATF uPA;;uPA |
| WB Predicted band size | 49 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human uPA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Urokinase(uPA)抗体的3篇参考文献示例(注：以下为模拟内容，实际文献需通过学术数据库查询)：
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1. **文献名称**：*Monoclonal Antibodies Against Urokinase Plasminogen Activator: Tools for Functional Studies in Cancer Invasion*
**作者**：Smith J, et al.
**摘要**：本研究开发了针对uPA的单克隆抗体，验证其在抑制肿瘤细胞侵袭中的作用。体外实验表明，这些抗体能有效阻断uPA与受体的结合，显著降低乳腺癌细胞的迁移和基质降解能力。
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2. **文献名称**：*Immunohistochemical Detection of uPA in Colorectal Cancer: Correlation with Metastasis and Prognosis*
**作者**：Lee H, et al.
**摘要**：通过免疫组化方法，利用高特异性uPA抗体分析结直肠癌组织样本。结果显示，uPA高表达与淋巴结转移和患者生存率降低显著相关，提示其作为预后生物标志物的潜力。
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3. **文献名称**：*Neutralizing Anti-uPA Antibodies Attenuate Fibrinolysis in a Murine Thrombosis Model*
**作者**：Garcia R, et al.
**摘要**：研究评估了中和性uPA抗体在小鼠血栓模型中的效果。发现抗体通过抑制uPA介导的纤溶酶原激活，延缓血栓溶解，为探索uPA在血栓调控中的机制提供了新视角。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“uPA antibody”、“urokinase antibody cancer”等获取近期研究。
Urokinase (uPA), a serine protease encoded by the PLAU gene, plays a key role in the plasminogen activation system, converting plasminogen to plasmin to degrade fibrin clots. Beyond fibrinolysis, uPA is involved in extracellular matrix remodeling, cell migration, and tissue repair. It is secreted as an inactive pro-enzyme (pro-uPA) and activated upon binding to its receptor (uPAR), forming a cell-surface signaling complex linked to pathological processes like cancer metastasis, chronic inflammation, and fibrosis.
Urokinase antibodies are immunological tools designed to target uPA or its components (e.g., pro-uPA, active uPA, uPAR). These antibodies are widely used in research to study uPA expression, localization, and function in diseases. For example, immunohistochemistry with anti-uPA antibodies helps visualize uPA distribution in tumor tissues, correlating its overexpression with poor prognosis in cancers. In therapeutic contexts, neutralizing anti-uPA/uPAR antibodies are explored to inhibit tumor invasion by blocking proteolytic activity or disrupting uPA-uPAR interactions. Some preclinical studies also investigate their potential in attenuating fibrosis or inflammatory disorders. Challenges include ensuring specificity due to structural similarities among serine proteases and optimizing delivery for clinical applications. Overall, urokinase antibodies serve as critical reagents for understanding uPA biology and developing targeted therapies.
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