| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TXN; ADF; ATL-derived factor; SASP; Thioredoxin; TRX1; Thioredoxin delta 3; TRX; TXN delta 3; TRDX;;Thioredoxin |
| WB Predicted band size | 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Thioredoxin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TRX1抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *"Thioredoxin 1 as a biomarker for oxidative stress in clinical populations"*
**作者**: Nakamura H. et al.
**摘要**: 该研究利用TRX1特异性抗体检测了多种疾病患者血清中的TRX1水平，发现其在癌症和炎症性疾病中显著升高，提示TRX1可作为氧化应激的生物标志物，并探讨了抗体在ELISA和免疫组化中的应用。
2. **文献名称**: *"Antibody-based inhibition of TRX1 enhances cisplatin sensitivity in lung cancer cells"*
**作者**: Zhang Y. et al.
**摘要**: 研究通过抗TRX1抗体阻断TRX1的抗氧化功能，发现可增强肺癌细胞对化疗药物顺铂的敏感性，揭示了TRX1在肿瘤耐药中的作用，并提出抗体干预作为潜在治疗策略。
3. **文献名称**: *"Structural mapping of TRX1 functional domains using monoclonal antibodies"*
**作者**: Smith J.R. et al.
**摘要**: 该文献报道了针对TRX1不同表位的单克隆抗体的开发，通过抗体结合实验解析了TRX1蛋白的活性区域结构，为研究其分子互作及功能调控提供了工具。
(注：上述文献信息为基于领域知识的模拟示例，实际引用需检索具体数据库获取原文。)
The TRX1 antibody is a crucial tool in studying thioredoxin 1 (Trx1), a 12-kDa redox protein central to maintaining cellular redox homeostasis. Trx1. encoded by the *TXN* gene, functions as a key antioxidant by reducing disulfide bonds in target proteins via its conserved Cys-Gly-Pro-Cys active site. It plays vital roles in regulating cell proliferation, apoptosis, and inflammation by interacting with signaling molecules like ASK1 and NF-κB. Trx1 is implicated in numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, where its dysregulation often correlates with oxidative stress and pathological progression.
TRX1 antibodies are widely used to detect Trx1 expression and localization in tissues or cultured cells through techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help researchers investigate Trx1's involvement in disease mechanisms, therapeutic responses, and its potential as a biomarker. Some studies highlight elevated Trx1 levels in tumors, linking it to chemotherapy resistance and poor prognosis.
Available as monoclonal or polyclonal forms from various suppliers, TRX1 antibodies differ in species reactivity (human, mouse, rat) and application-specific validation. Researchers must select antibodies validated for their experimental model and method. Additionally, Trx1’s extracellular roles in immune modulation and redox signaling have spurred interest in developing Trx1-targeted therapies, making its antibody a valuable reagent in both basic research and drug development. Proper controls are essential to ensure specificity, given structural similarities among thioredoxin family members.
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