| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HOX2; HU-2; HOX2B; Hox-2.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXB6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PROX1抗体的3篇参考文献示例(内容为模拟概括，仅供参考)：
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1. **文献名称**: *PROX1 is a marker of lymphatic endothelial cells in colorectal cancer and promotes tumor progression*
**作者**: Smith A, et al.
**摘要**: 该研究利用PROX1抗体通过免疫组化技术，证实PROX1在结直肠癌淋巴管内皮细胞中的特异性表达，并发现其高表达与肿瘤转移和不良预后相关。
2. **文献名称**: *PROX1 regulates the development of the mammalian lymphatic system*
**作者**: Johnson B, et al.
**摘要**: 通过PROX1抗体的免疫荧光染色，本研究揭示了PROX1在小鼠胚胎淋巴管发育中的关键作用，证明其缺失导致淋巴管结构异常。
3. **文献名称**: *Dual role of PROX1 in hepatocellular carcinoma: Tumor suppressor and oncogenic driver*
**作者**: Chen L, et al.
**摘要**: 该研究使用PROX1抗体进行Western blot和免疫组化分析，发现PROX1在肝细胞癌中呈现双重功能，其表达水平差异与不同分子亚型的临床结果相关。
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**备注**：以上文献信息为示例性概括，具体研究请通过PubMed或Google Scholar以“PROX1 antibody”为关键词检索最新论文。如需真实文献，可提供PMID或DOI进一步协助查询。
PROX1 (Prospero homeobox 1) antibody is a tool used to detect the PROX1 protein, a homeodomain transcription factor critical for embryonic development and cellular differentiation. Initially identified in Drosophila, PROX1 regulates cell fate decisions in various tissues, including the lymphatic system, liver, nervous system, and pancreas. It is best known for its role in lymphatic endothelial cell specification, where it drives the differentiation of venous endothelial cells into lymphatic endothelial cells during vasculogenesis. Dysregulation of PROX1 is linked to developmental anomalies, cancer progression, and metabolic disorders.
In research, PROX1 antibodies are widely employed in techniques like immunohistochemistry, immunofluorescence, and Western blotting to study protein expression, localization, and function. They are particularly valuable in cancer biology, as PROX1 exhibits dual roles—acting as a tumor suppressor in some contexts (e.g., colorectal and liver cancers) or promoting malignancy in others (e.g., glioblastoma). Additionally, PROX1 is implicated in metabolic regulation, influencing gluconeogenesis and lipid metabolism in the liver.
Clinically, PROX1 antibodies aid in diagnosing lymphatic disorders (e.g., lymphedema) and characterizing tumors with lymphatic features. Their utility in exploring Hippo signaling interactions and organogenesis further underscores their importance in developmental and disease-related studies. Despite its diverse roles, PROX1's mechanisms remain partially understood, driving ongoing research to clarify its tissue-specific functions and therapeutic potential.
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