| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | P4HB; PDIA2; PDIR;;PDIA2 |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human PDIA2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于PDI(Protein Disulfide Isomerase)抗体的代表性文献，涵盖不同研究方向的摘要内容：
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1. **文献名称**：*Protein disulfide isomerase as a target for antibody therapy in neurodegenerative diseases*
**作者**：H. Yoshida et al.
**摘要**：研究揭示了PDI在阿尔茨海默病中与tau蛋白异常磷酸化的关联。使用特异性PDI抗体阻断其活性后，显著减少神经元内tau蛋白聚集，提示PDI抗体可能成为神经退行性疾病的新型治疗工具。
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2. **文献名称**：*PDI regulates macrophage polarization and promotes tumor progression via redox signaling*
**作者**：S. Chen et al.
**摘要**：通过PDI抗体抑制肿瘤相关巨噬细胞中的PDI功能，发现其可逆转M2型巨噬细胞促肿瘤表型，并增强抗肿瘤免疫反应。研究为PDI抗体在癌症免疫治疗中的应用提供了实验依据。
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3. **文献名称**：*Autoantibodies against PDI in autoimmune hepatitis: Diagnostic and prognostic implications*
**作者**：M. Rodriguez et al.
**摘要**：在自身免疫性肝炎患者血清中检测到高水平的抗PDI自身抗体，且抗体滴度与疾病活动度正相关。PDI抗体或可作为该疾病的生物标志物及潜在治疗靶点。
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**注**：以上文献名为虚构示例，实际研究中需通过PubMed或Web of Science检索真实文献(可尝试关键词：PDI antibody, PDI autoantibody, PDI inhibitor)。若需具体文章推荐，请进一步说明研究场景(如疾病类型或实验目的)。
Protein disulfide isomerase (PDI) is a multifunctional enzyme belonging to the thioredoxin superfamily, primarily located in the endoplasmic reticulum (ER). It plays a critical role in catalyzing the formation, breakage, and rearrangement of disulfide bonds during protein folding, ensuring proper tertiary structure and functional maturation of nascent polypeptides. Beyond its chaperone activity, PDI participates in ER stress responses, calcium homeostasis, and redox signaling. Dysregulation of PDI has been implicated in various pathologies, including neurodegenerative diseases (e.g., Alzheimer’s and Parkinson’s), cancer metastasis, and cardiovascular disorders, where disrupted protein folding contributes to cellular dysfunction.
PDI antibodies are essential tools for studying its expression, localization, and mechanistic roles in health and disease. They enable detection of PDI in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research on ER stress pathways or protein misfolding. Some studies also explore PDI as a therapeutic target, with antibodies designed to modulate its activity in pathological contexts. However, challenges remain in distinguishing PDI from its isoforms (e.g., PDIA1-PDIA6) due to structural similarities, necessitating careful antibody validation. Overall, PDI antibodies bridge fundamental research and translational applications, offering insights into protein quality control mechanisms and potential therapeutic strategies.
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