| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HOX2; HOX2F; HOX-2.6 |
| Entrez GeneID | 3214 |
| clone | 3A2F2 |
| WB Predicted band size | 27.6kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HOXB4 (AA: 16-251) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BMP11抗体的示例性参考文献(虚构内容，仅作演示用途)：
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1. **文献名称**: *"Development of a High-Specificity Monoclonal Antibody for BMP11 in Mammalian Tissue Analysis"*
**作者**: Smith, J. et al.
**摘要**: 研究团队开发了一种针对BMP11的单克隆抗体，通过免疫印迹(Western blot)和免疫组化验证其在哺乳动物组织中的特异性，成功用于检测骨骼肌再生模型中BMP11的动态表达变化。
2. **文献名称**: *"BMP11 Antibody-Based ELISA for Quantifying Circulating GDF11 Levels in Age-Related Cardiovascular Disease"*
**作者**: Zhang, L. et al.
**摘要**: 本文建立了一种基于多克隆抗体的ELISA检测方法，定量分析血清中BMP11(GDF11)水平，发现其与动脉粥样硬化患者的疾病严重程度呈负相关，为临床诊断提供潜在工具。
3. **文献名称**: *"Antibody-Mediated Neutralization of BMP11 Reveals Its Role in Neural Stem Cell Differentiation"*
**作者**: Tanaka, K. et al.
**摘要**: 利用中和性抗体阻断BMP11功能，证明其在神经干细胞向神经元分化中的关键作用，抗体特异性通过siRNA敲降实验交叉验证，支持其在神经发育研究中的应用。
4. **文献名称**: *"Comparative Evaluation of Commercial BMP11 Antibodies: Specificity and Cross-Reactivity Challenges"*
**作者**: Garcia, R. et al.
**摘要**: 系统性评估了市售BMP11抗体的性能，发现部分抗体与BMP8/9存在交叉反应，提出优化抗体选择策略以提高实验可靠性，强调质控标准的重要性。
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**注**：以上内容为示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。
The BMP11 antibody targets Bone Morphogenetic Protein 11 (BMP11), a member of the transforming growth factor-beta (TGF-β) superfamily. BMP11. also known as Growth Differentiation Factor 11 (GDF11), plays critical roles in embryonic development, tissue homeostasis, and metabolic regulation. It regulates skeletal patterning, muscle development, and neural differentiation by activating SMAD-dependent signaling pathways through binding to activin type II receptors (ACVR2A/B) and ALK4/5/7. Dysregulation of BMP11 is linked to developmental disorders, age-related diseases, and metabolic syndromes. For instance, reduced BMP11 levels correlate with sarcopenia and impaired tissue repair, while overexpression may influence skeletal abnormalities.
BMP11 antibodies are essential tools for studying its expression, localization, and function in vitro and in vivo. They enable detection via techniques like Western blot, immunohistochemistry, and ELISA, aiding research on BMP11's role in cellular differentiation, organogenesis, and disease mechanisms. Additionally, therapeutic applications are explored, such as modulating BMP11 activity to treat muscle wasting, osteoporosis, or metabolic disorders. However, challenges remain, including clarifying its dual roles in aging and cancer, where context-dependent pro- or anti-tumor effects are reported. Overall, BMP11 antibodies are pivotal in unraveling its biological complexity and translational potential.
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