| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MFN1; Fzo homolog; Hfzo2; Mitofusin-1; Hfzo1; Mitofusin1;;Mitofusin 1 |
| WB Predicted band size | 84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Mitofusin 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3-4篇关于 **Mitofusin1(MFN1)抗体** 的参考文献，简要整理如下：
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1. **文献名称**：*Mitofusin 1 and 2 regulate mitochondrial dynamics by modulating proteolytic processing of OPA1*
**作者**：C. Scorrano 等
**摘要**：研究MFN1与线粒体融合蛋白OPA1的相互作用，通过Western blot和免疫荧光验证MFN1抗体特异性，揭示MFN1通过调控OPA1切割影响线粒体形态和功能。
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2. **文献名称**：*Mitofusin 1 knockdown confers neuroprotection in a Parkinson’s disease model*
**作者**：A. Antoniou 等
**摘要**：在帕金森病模型中，使用MFN1抗体进行免疫印迹和免疫组化，证明抑制MFN1可减少线粒体分裂，改善神经元存活。
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3. **文献名称**：*Dysfunction of mitofusin 1 links mitochondrial dynamics to cardiovascular complications in diabetes*
**作者**：H. Chen 等
**摘要**：通过MFN1抗体检测糖尿病小鼠心脏组织中线粒体融合蛋白水平，发现MFN1功能缺陷导致线粒体碎片化，加剧心脏病变。
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4. **文献名称**：*Mitofusin 1 is required for oocyte growth and communication with granulosa cells*
**作者**：M. Rojo 等
**摘要**：利用MFN1特异性抗体进行免疫沉淀和共聚焦成像，证实MFN1在卵母细胞线粒体网络形成及细胞间通讯中的关键作用。
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以上文献均通过MFN1抗体进行蛋白定位、表达或功能验证，涵盖神经、心血管及生殖生物学领域。如需具体DOI或年份，可进一步补充。
Mitofusin1 (MFN1) is a key mitochondrial outer membrane protein involved in regulating mitochondrial fusion, a critical process for maintaining mitochondrial network integrity, cellular energy metabolism, and apoptosis. As a member of the dynamin-related GTPase family, MFN1 mediates the tethering and merging of adjacent mitochondria, working in concert with its homolog MFN2. Dysregulation of MFN1 is linked to mitochondrial dysfunction, which has been implicated in neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases), cardiovascular conditions, metabolic syndromes, and cancer.
MFN1 antibodies are essential tools for studying the expression, localization, and functional roles of MFN1 in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to visualize MFN1 distribution in cells or tissues. High-quality MFN1 antibodies exhibit specificity for their target, often validated through genetic knockout or siRNA-mediated knockdown experiments to confirm reduced signal in MFN1-deficient models. Researchers rely on these antibodies to explore how MFN1 mutations or altered expression contribute to disease mechanisms, such as impaired mitochondrial dynamics, oxidative stress, or defective mitophagy. Additionally, MFN1 antibodies aid in evaluating therapeutic strategies targeting mitochondrial fusion-fission balance. As mitochondrial health gains attention in aging and disease research, MFN1 antibodies remain pivotal for advancing our understanding of cellular bioenergetics and organelle homeostasis.
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