| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Vascular endothelial cadherin; VE-cadherin; 7B4 antigen; CD144 antigen; CDH5;;Cadherin 5 |
| WB Predicted band size | Calculated MW: 88 kDa ; Observed MW: 90,125 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | A synthesized peptide derived from mouse Cadherin 5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于VE-Cadherin抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *VE-cadherin: Endothelial cell junction control in vitro and in vivo*
**作者**: Lampugnani, M.G., et al.
**摘要**: 该研究通过特异性抗体阻断VE-Cadherin功能，揭示其在维持内皮细胞间连接和血管屏障完整性中的关键作用，并证明其缺失导致血管通透性异常。
2. **文献名称**: *Targeting VE-cadherin in tumor angiogenesis: A monoclonal antibody approach*
**作者**: Gaggiano, G., et al.
**摘要**: 研究团队开发了一种抗VE-Cadherin的单克隆抗体，在体外和小鼠模型中证实其可抑制肿瘤血管新生，为抗血管生成治疗提供了潜在策略。
3. **文献名称**: *VE-cadherin antibodies disrupt endothelial cell alignment in atherosclerosis models*
**作者**: Margariti, A., et al.
**摘要**: 通过抗体阻断VE-Cadherin，研究发现内皮细胞排列紊乱加剧动脉粥样硬化斑块形成，提示其在炎症性血管疾病中的调控机制。
4. **文献名称**: *Functional analysis of endothelial junctions using VE-cadherin-specific antibodies*
**作者**: Dejana, E., et al.
**摘要**: 该综述系统总结了VE-Cadherin抗体在解析细胞间信号传导、血管发育及病理过程中的应用，强调其作为研究工具的重要性。
(注：以上文献信息为示例性内容，实际引用需核对真实文献来源。)
VE-cadherin (Vascular Endothelial cadherin), also known as CDH5 or CD144. is a calcium-dependent transmembrane protein critical for maintaining endothelial cell-cell adhesion. As a key component of endothelial adherens junctions, it mediates homophilic interactions between adjacent cells through its extracellular cadherin repeats, while its intracellular domain binds to catenins (e.g., β-catenin) to link the actin cytoskeleton. This structural role stabilizes vascular integrity, regulates vascular permeability, and supports angiogenesis. Dysregulation of VE-cadherin is implicated in pathological conditions such as inflammation, tumor angiogenesis, and atherosclerosis.
VE-cadherin antibodies are indispensable tools for studying endothelial biology. They enable detection of VE-cadherin expression and localization via techniques like immunohistochemistry, immunofluorescence, and Western blotting. Function-blocking antibodies are widely used to disrupt VE-cadherin-mediated adhesion in vitro, revealing its role in endothelial barrier function, leukocyte transmigration, and vascular remodeling. In disease research, these antibodies help assess vascular abnormalities in cancer models or inflammatory disorders. Additionally, therapeutic applications are being explored, including targeting VE-cadherin to modulate vascular permeability in edema or inhibit pathological angiogenesis. Validation of antibody specificity remains crucial due to structural similarities among cadherin family members. Overall, VE-cadherin antibodies continue to advance both basic research and translational studies in vascular biology.
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