| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FASN; FAS; OA-519; SDR27X1; Fatty acid synthase;;Fatty acid synthase |
| WB Predicted band size | 273 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Fatty acid synthase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于FASN抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*Fatty acid synthase overexpression is a prognostic marker and therapeutic target in breast cancer*
**作者**：Menendez, J.A., et al.
**摘要**：研究揭示了FASN在乳腺癌中的过表达与肿瘤进展和不良预后的关联，提出FASN抗体可用于检测肿瘤组织中FASN水平，并验证其作为治疗靶点的潜力。
2. **文献名称**：*Inhibition of fatty acid synthase induces caspase-8-mediated apoptosis in prostate cancer cells*
**作者**：Bandyopadhyay, S., et al.
**摘要**：通过FASN抗体阻断实验，研究发现抑制FASN活性可激活凋亡信号通路，显著降低前列腺癌细胞存活率，为FASN靶向治疗提供机制支持。
3. **文献名称**：*FASN regulates HER2 signaling pathway in ovarian cancer*
**作者**：Wang, Y., et al.
**摘要**：利用FASN特异性抗体，研究证实FASN通过调控HER2信号通路促进卵巢癌细胞增殖和转移，提示联合靶向FASN与HER2可能增强抗癌疗效。
这些研究均通过FASN抗体探索其在癌症中的作用机制或临床应用。
Fatty Acid Synthase (FASN) is a multifunctional enzyme complex critical for *de novo* fatty acid biosynthesis, catalyzing the conversion of acetyl-CoA and malonyl-CoA into palmitate. It plays a central role in lipid metabolism, energy storage, and membrane synthesis. FASN is highly expressed in lipogenic tissues (e.g., liver, adipose) under normal physiological conditions but is often upregulated in cancers, where it supports rapid proliferation, survival, and metastasis by providing lipids for membrane synthesis and signaling molecules. Dysregulated FASN is also linked to metabolic disorders like obesity and diabetes.
FASN antibodies are immunological tools designed to detect and quantify FASN protein levels in research and diagnostic applications. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence to study FASN expression patterns in normal vs. diseased tissues. In cancer research, FASN antibodies help assess its prognostic value and therapeutic potential, as FASN inhibition has shown antitumor effects. Additionally, they aid in exploring FASN's interaction with oncogenic pathways (e.g., PI3K/AKT/mTOR) and metabolic adaptations in tumor microenvironments. Validated FASN antibodies are essential for understanding lipid metabolism rewiring in disease pathogenesis and evaluating targeted therapies.
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