| WB | 咨询技术 | Mouse,Rat |
| IF | 咨询技术 | Mouse,Rat |
| IHC | 咨询技术 | Mouse,Rat |
| ICC | 1/50-1/200 | Mouse,Rat |
| FCM | 咨询技术 | Mouse,Rat |
| Elisa | 咨询技术 | Mouse,Rat |
| Aliases | ARM-repeat protein; Catenin delta 2; CTNND 2; Ctnnd2; Delta catenin; Delta-catenin; GT24; Neural plakophilin related arm repeat protein; Neurojungin; NPRAP; T cell delta catenin;;delta 2 Catenin |
| WB Predicted band size | 135 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse,Rat |
| Immunogen | A synthesized peptide derived from mouse delta 2 Catenin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于delta2-Catenin抗体的3篇参考文献及其摘要概括：
---
1. **文献名称**: *Delta2-Catenin regulates synaptic plasticity and Alzheimer's disease via interaction with PSD-95*
**作者**: Jones, S. et al.
**摘要**: 该研究通过开发特异性delta2-Catenin抗体，发现其与突触后蛋白PSD-95的相互作用在阿尔茨海默病模型中显著减弱，提示其在突触功能及神经退行性疾病中的关键作用。
---
2. **文献名称**: *Aberrant expression of delta2-Catenin in prostate cancer progression*
**作者**: Chen, L. et al.
**摘要**: 利用delta2-Catenin单克隆抗体进行免疫组化分析，揭示其在前列腺癌组织中的异常高表达，并证实其通过Wnt信号通路促进肿瘤侵袭转移。
---
3. **文献名称**: *Developmental expression of delta2-Catenin in the mouse brain*
**作者**: Wang, Y. et al.
**摘要**: 研究通过免疫荧光和Western blot技术，系统描述了delta2-Catenin在小鼠胚胎及出生后神经发育阶段的动态表达模式，提示其在神经元迁移和轴突形成中的功能。
---
(注：以上文献信息为示例性概括，实际文献需通过数据库如PubMed或Google Scholar检索确认。)
Delta2-catenin (also known as CTNND2) is a member of the catenin family, primarily expressed in the nervous system. It plays a critical role in cell-cell adhesion and synaptic plasticity by interacting with cadherins, particularly δ-protocadherins, to stabilize synaptic junctions. Unlike β-catenin, delta2-catenin lacks the α-catenin-binding domain, suggesting distinct regulatory mechanisms in cytoskeletal organization and signaling. Its expression is tightly linked to neuronal development, with studies highlighting its importance in dendrite morphogenesis, spine formation, and synaptic stability.
Antibodies targeting delta2-catenin are essential tools for investigating its localization, expression levels, and interactions in both physiological and pathological contexts. Researchers use these antibodies in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to study its role in neurodevelopmental disorders (e.g., autism, intellectual disability) and neurodegenerative diseases (e.g., Alzheimer’s). Delta2-catenin dysregulation has also been implicated in cancer, particularly in tumors with neural or epithelial origins, where altered adhesion signaling promotes invasiveness.
The development of specific and validated delta2-catenin antibodies has advanced understanding of its dual roles in structural adhesion and synaptic signaling, offering insights into therapeutic targets for neurological and oncological conditions.
×
