| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; c-MAF; c-maf proto-oncogene; cMaf; MAF; MGC71685; Proto-oncogene c-Maf;;c Maf |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human c Maf |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于c-Maf抗体的3篇代表性文献(注：文献信息为模拟示例，实际引用需核实)：
1. **文献名称**：*c-Maf regulates the plasticity of Th17 cell differentiation through antibody-mediated inhibition in autoimmune diseases*
**作者**：Smith A, et al.
**摘要**：研究利用c-Maf特异性抗体(WB/IHC验证)证明c-Maf通过调控IL-21表达影响Th17细胞分化，为自身免疫病治疗提供新靶点。
2. **文献名称**：*c-Maf as a biomarker in multiple myeloma: Validation of a commercial antibody for clinical diagnostics*
**作者**：Lee JH, et al.
**摘要**：评估两种市售c-Maf抗体(克隆号：sym0F1)在多发性骨髓瘤组织中的敏感性和特异性，证实其作为预后标志物的潜力。
3. **文献名称**：*Mechanistic insights into c-Maf-driven oncogenesis via ChIP-seq and antibody blocking experiments*
**作者**：Wang X, et al.
**摘要**：通过ChIP-seq(使用抗c-Maf抗体)揭示c-Maf在癌细胞中直接激活促增殖基因，抗体阻断可抑制肿瘤生长。
如需真实文献，建议检索PubMed或Google Scholar，关键词：**c-Maf antibody**, **immunohistochemistry**, **transcription factor**。
c-Maf antibodies are essential tools for studying the transcription factor c-Maf, a member of the large Maf protein family. c-Maf (cellular musculoaponeurotic fibrosarcoma oncogene homolog) regulates gene expression by binding to Maf recognition elements (MAREs) in DNA. It plays critical roles in cellular differentiation, immune regulation, and tissue development. Notably, c-Maf is involved in T-cell subset differentiation (e.g., Th17 cells) and the maintenance of immune tolerance. It also contributes to the development of plasma cells and lens fiber cells. Dysregulation of c-Maf is linked to diseases, including multiple myeloma, where its overexpression promotes oncogenesis, and autoimmune disorders.
c-Maf antibodies are widely used in research to detect and quantify c-Maf protein levels in cells or tissues via techniques like Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF). They help elucidate c-Maf's role in signaling pathways, disease mechanisms, and potential therapeutic targets. Commercial antibodies are typically raised against specific epitopes of human or mouse c-Maf, with validation in knockout controls to ensure specificity. Researchers must select antibodies based on host species, clonality (monoclonal/polyclonal), and compatibility with intended applications. Reliable c-Maf antibodies are crucial for advancing studies in immunology, cancer biology, and developmental biology, making them indispensable for both basic research and clinical diagnostics.
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