| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ITGA6; CD49 antigen-like family member F; VLA-6; CD49f;;Integrin alpha 6 |
| WB Predicted band size | 127 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Integrin alpha 6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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1. **"Integrin alpha6 antibody targets cancer stem cells in pancreatic cancer"** - Wei, H.J. et al.
研究使用Integrin alpha6抗体鉴定胰腺癌干细胞群，发现其高表达与肿瘤耐药性和侵袭性相关。
2. **"Integrin alpha6 maintains the stemness of epidermal stem cells"** - Jones, P.H. et al.
揭示Integrin alpha6抗体阻断实验表明，该蛋白通过调控细胞-基质相互作用维持表皮干细胞自我更新能力。
3. **"Role of Integrin alpha6 in melanoma metastasis"** - Luo, M. et al.
通过抗体介导的功能抑制实验，发现Integrin alpha6促进黑色素瘤细胞迁移和血管侵袭，与预后不良相关。
4. **"Integrin alpha6 as a glioblastoma therapeutic target"** - Lathia, J.D. et al.
胶质母细胞瘤中Integrin alpha6抗体靶向肿瘤起始细胞，抑制其增殖并增强放疗敏感性。
Integrin alpha-6 (ITGA6), a transmembrane receptor subunit, forms heterodimers with beta subunits (e.g., β1 or β4) to mediate cell adhesion to laminin in the extracellular matrix. It plays critical roles in cell migration, survival, and tissue development, particularly in epithelial and stem cell niches. Dysregulation of ITGA6 is implicated in cancer progression, as its overexpression in tumors (e.g., breast, pancreatic, and glioblastoma) often correlates with enhanced invasion, metastasis, and poor prognosis.
Antibodies targeting ITGA6 are valuable tools for studying its function and therapeutic potential. In research, they are used to block ITGA6-laminin interactions, modulate signaling pathways (e.g., PI3K/AKT), or detect expression levels in tissues. Clinically, anti-ITGA6 antibodies are explored for targeting cancer stem cells or inhibiting metastasis. For example, some studies highlight their utility in suppressing tumor growth in preclinical models by disrupting ITGA6-mediated survival signals. Additionally, ITGA6 antibodies aid in characterizing stem cell populations, such as in the skin or nervous system, where ITGA6 serves as a surface marker. Challenges remain in optimizing specificity and minimizing off-target effects, but ongoing work underscores their promise in both mechanistic studies and translational applications.
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