| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-B9; Hox-2E; Hox-2.5; HOXB9; HOX2E;;HOX B9 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human HOX B9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3条关于HOXB9抗体的虚构参考文献(仅供示例参考，非真实文献)：
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1. **文献名称**: *HOXB9 Expression in Triple-Negative Breast Cancer: A Prognostic Marker Study*
**作者**: Zhang L, et al.
**摘要**: 本研究通过免疫组化(使用兔源HOXB9单克隆抗体)分析HOXB9在乳腺癌组织中的表达，发现其在三阴性乳腺癌中显著高表达，且与患者不良预后相关，提示HOXB9可能作为潜在治疗靶点。
2. **文献名称**: *HOXB9 Antibody Validation for Epigenetic Regulation in Colorectal Cancer*
**作者**: Smith JR, et al.
**摘要**: 文章报道了一种新型HOXB9多克隆抗体的开发与验证(Western blot/免疫荧光)，证实其特异性后，研究发现HOXB9通过调控Wnt/β-catenin通路促进结直肠癌细胞侵袭，抗体可用于临床样本的分子分型。
3. **文献名称**: *HOXB9 in Hematopoietic Stem Cell Differentiation: Role and Antibody-Based Detection*
**作者**: Tanaka K, et al.
**摘要**: 利用HOXB9特异性抗体进行流式细胞术和染色质免疫沉淀(ChIP)，揭示HOXB9在造血干细胞分化中的动态表达模式，其缺失导致红细胞系分化异常，为血液疾病机制提供新见解。
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(注：以上文献信息为模拟内容，实际引用需查询真实数据库如PubMed。)
The HOXB9 antibody is a crucial tool in studying the role of the HOXB9 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors that regulate embryonic development, particularly body patterning and cell differentiation. HOXB9. located on chromosome 17. is involved in anterior-posterior axis formation and hematopoiesis. Recent studies highlight its dual role in cancer biology: while it promotes angiogenesis and tumor growth in breast, lung, and colorectal cancers, it also exhibits tumor-suppressive effects in certain contexts, such as acute myeloid leukemia.
HOXB9 antibodies are widely used in research to detect and quantify HOXB9 protein expression via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These antibodies help elucidate HOXB9's regulatory mechanisms, including its interaction with signaling pathways like TGF-β and Wnt. Commercial HOXB9 antibodies are typically raised against specific epitopes, ensuring specificity for human, mouse, or rat samples.
Investigations using HOXB9 antibodies have revealed its potential as a biomarker for cancer prognosis and therapeutic targeting. However, discrepancies in its functional roles across cancer types underscore the need for context-specific studies. Ongoing research focuses on clarifying HOXB9's pleiotropic effects and exploring its utility in precision oncology.
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