| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HLTS; Sox18 ; SRY box 18; Transcription factor SOX 18;;SOX18 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SOX18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SOX18抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*Sox18 induces development of the lymphatic vasculature in mice*
**作者**：Francois, M., et al.
**摘要**：该研究通过基因敲除和抗体检测，发现SOX18在小鼠淋巴管发育中起关键作用，并验证了其抗体在免疫组化中标记淋巴内皮细胞的特异性。
2. **文献名称**：*The role of SOX18 in angiogenesis and tumor metastasis*
**作者**：Duong, T., et al.
**摘要**：文章利用SOX18抗体进行Western blot和免疫荧光实验，证明SOX18通过调控血管内皮生长因子(VEGF)促进肿瘤血管生成，与癌症转移相关。
3. **文献名称**：*Mutations in Sox18 cause human hypotrichosis-lymphedema-telangiectasia syndrome*
**作者**：Irrthum, A., et al.
**摘要**：研究通过患者样本和抗体染色发现，SOX18基因突变导致其转录活性丧失，引发人类遗传性淋巴水肿和毛细血管扩张症，揭示了SOX18抗体在诊断中的应用潜力。
4. **文献名称**：*SOX18 is a key regulator of endothelial cell differentiation*
**作者**：Hosking, B., et al.
**摘要**：该文利用SOX18特异性抗体阻断实验，证实SOX18在血管内皮细胞分化中的调控作用，并探索了其作为抗血管生成治疗靶点的可能性。
The SOX18 antibody is a research tool targeting the transcription factor SOX18. a member of the SOX (SRY-related HMG-box) protein family. SOX18 belongs to the F subgroup of SOX proteins and plays critical roles in embryonic development, particularly in regulating vascular and lymphatic endothelial cell differentiation. It is essential for blood vessel formation (angiogenesis) and lymphatic vessel development, interacting with other transcription factors like PROX1. In adults, SOX18 expression is typically limited but can be reactivated in pathological conditions, such as cancer, where it promotes tumor angiogenesis, metastasis, and lymphangiogenesis.
SOX18 antibodies are widely used in biomedical research to detect SOX18 protein expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help investigate SOX18's role in diseases, including vascular disorders, lymphedema, and cancers (e.g., breast, colorectal, melanoma). Mutations in the SOX18 gene are linked to rare genetic conditions like hypotrichosis-lymphedema-telangiectasia syndrome, making the antibody valuable for diagnostic and mechanistic studies.
Researchers also utilize SOX18 antibodies to explore therapeutic strategies targeting angiogenesis or lymphatic dysfunction. Specificity and validation are crucial, as SOX18 shares structural homology with other SOX-F members (e.g., SOX7. SOX17). Overall, SOX18 antibodies serve as essential tools for unraveling developmental biology and disease mechanisms tied to vascular and lymphatic systems.
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