| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Shb;;SHB |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SHB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SHB抗体的示例参考文献(注：以下为虚构示例，实际文献请通过学术数据库检索)：
1. **文献名称**: "SHB Adaptor Protein Regulates Tumor Angiogenesis via VEGF Signaling"
**作者**: Smith J, et al.
**摘要**: 本研究利用SHB特异性抗体，通过免疫印迹和免疫荧光技术，揭示了SHB蛋白在肿瘤血管生成中的作用机制，证实其通过调节VEGFR2信号通路影响内皮细胞迁移。
2. **文献名称**: "SHB Deficiency Alters Insulin Sensitivity in Adipose Tissue"
**作者**: Lee H, et al.
**摘要**: 作者通过SHB基因敲除小鼠模型及SHB抗体检测，发现SHB蛋白缺失导致脂肪组织胰岛素信号通路异常，提示其在代谢综合征中的潜在调控作用。
3. **文献名称**: "Localization of SHB in Neuronal Synapses and Its Role in Neurodevelopment"
**作者**: Zhang Y, et al.
**摘要**: 采用SHB抗体进行脑组织免疫组化分析，发现SHB富集于突触区域，并通过体外实验证明其参与神经元突触形成和成熟过程。
4. **文献名称**: "SHB as a Therapeutic Target in Triple-Negative Breast Cancer"
**作者**: Garcia R, et al.
**摘要**: 研究通过临床样本的SHB抗体染色及功能实验，证实SHB高表达与乳腺癌患者预后不良相关，并探索了靶向SHB的潜在治疗策略。
建议通过PubMed、Google Scholar等平台，以关键词“SHB antibody”、“SHB protein function”或“SHB signaling”检索真实文献。
SHB antibody targets the SH2 domain-containing adapter protein B (SHB), a signaling molecule involved in various cellular processes. SHB contains multiple functional domains, including a phosphotyrosine-binding SH2 domain, which enables interaction with phosphorylated tyrosine residues on activated receptors or intracellular kinases. It plays a regulatory role in growth factor signaling pathways (e.g., VEGF, FGF, PDGF) and modulates downstream processes like cell proliferation, differentiation, migration, and apoptosis. SHB is expressed across tissues and implicated in angiogenesis, insulin secretion, and immune responses.
SHB antibodies are essential tools for studying its expression, localization, and interactions in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate SHB's role in cancer progression, diabetes, cardiovascular diseases, and developmental disorders. Research has linked SHB dysregulation to tumor angiogenesis, metastasis, and impaired β-cell function, making it a potential therapeutic target. Commercial SHB antibodies are typically developed in rabbits or mice, validated for specificity via knockout controls. Their application advances understanding of SHB's multifaceted signaling networks and disease mechanisms.
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