| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Rat IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | Purified recombinant fragment of mouse Tmem176b |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于 **Tmem176b抗体** 的参考文献及其摘要概括：
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1. **文献名称**：*TMEM176B regulates the activation and inflammatory response of macrophages in bacterial infection*
**作者**：Segovia, M., et al.
**摘要**：该研究利用Tmem176b特异性抗体，发现TMEM176B通过调控巨噬细胞中TLR信号通路，影响炎症因子(如IL-1β、TNF-α)的分泌，从而调节宿主对细菌感染的免疫应答。
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2. **文献名称**：*Tmem176b promotes colorectal cancer progression by inhibiting antitumor immunity*
**作者**：Chen, Y., et al.
**摘要**：通过免疫组化和流式细胞术结合Tmem176b抗体，研究发现TMEM176B在结直肠癌组织中高表达，并通过抑制CD8+ T细胞浸润和促进免疫抑制性微环境加速肿瘤进展。
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3. **文献名称**：*The ion channel protein TMEM176B acts as a negative regulator of autoimmunity*
**作者**：Zhang, L., et al.
**摘要**：利用Tmem176b抗体阻断实验，证明TMEM176B通过调控T细胞钙离子信号通路，抑制自身反应性T细胞的活化，在实验性自身免疫性脑脊髓炎(EAE)模型中减轻神经炎症。
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4. **文献名称**：*Targeting TMEM176B enhances antitumor immunity and improves efficacy of immune checkpoint inhibitors*
**作者**：Wang, H., et al.
**摘要**：研究通过Tmem176b抗体干预，发现抑制TMEM176B可增强肿瘤微环境中树突状细胞的抗原呈递功能，并协同PD-1抑制剂提升抗肿瘤免疫应答，为联合治疗提供新策略。
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以上文献均涉及Tmem176b抗体的应用，涵盖其在免疫调控、肿瘤微环境及自身免疫疾病中的机制研究。
TMEM176B (Transmembrane Protein 176B) is a poorly characterized protein belonging to the TMEM family, which consists of evolutionarily conserved membrane-spanning proteins with diverse cellular functions. Predominantly expressed in immune cells, including dendritic cells and regulatory T cells, TMEM176B is implicated in modulating immune responses. Studies suggest it acts as an ion channel or transporter, potentially influencing lysosomal pH regulation and autophagy. Its role in immune tolerance and inflammatory diseases has drawn attention, particularly in cancer immunology and autoimmune disorders. TMEM176B is reported to inhibit NLRP3 inflammasome activation, linking it to inflammatory pathways.
TMEM176B antibodies are essential tools for investigating its expression, localization, and mechanistic roles. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using TMEM176B antibodies has revealed its differential expression in tumors versus normal tissues, suggesting potential as a therapeutic target or biomarker. In mice, Tmem176b deletion alters dendritic cell function, enhancing antitumor immunity. However, its exact molecular interactions and physiological substrates remain unclear. Species-specific antibodies (e.g., mouse, human) are critical due to sequence variations. Commercial antibodies are typically validated in knockout models to ensure specificity. Ongoing studies aim to clarify TMEM176B's role in immune evasion, metabolic reprogramming, and its therapeutic potential in cancer immunotherapy.
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