| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IRAG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IRAG2抗体的假设性参考文献示例(仅供格式参考，建议通过学术数据库获取最新文献)：
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1. **文献名称**: *IRAG2 modulates cGMP-dependent signaling in vascular smooth muscle cells*
**作者**: Schmidt H, et al.
**摘要**: 研究揭示了IRAG2蛋白通过结合IP3受体和cGMP依赖性激酶调控血管平滑肌细胞钙离子稳态，开发的IRAG2特异性抗体被用于验证其与信号复合物的相互作用。
2. **文献名称**: *Development of a monoclonal antibody for IRAG2 and its application in cardiac hypertrophy models*
**作者**: Nakamura K, et al.
**摘要**: 报道了一种高特异性IRAG2单克隆抗体的制备，并通过免疫组化证实IRAG2在心肌肥大模型中的表达上调，提示其在心脏疾病中的潜在作用。
3. **文献名称**: *IRAG2-antibody based detection of protein-protein interactions in platelet activation*
**作者**: Zhang M, et al.
**摘要**: 利用IRAG2抗体探究其与G蛋白偶联受体的结合机制，发现IRAG2在血小板活化过程中通过调控钙信号影响血栓形成。
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**注意**：以上文献为示例，IRAG2相关研究可能较少，建议通过**PubMed**或**Google Scholar**以关键词“IRAG2 antibody”、“IP3R-associated protein”等检索最新成果。
The IRAG2 (Inositol 1.4.5-Triphosphate Receptor-Associated GTPase 2) protein, also known as MRVI1 (Murine Retrovirus Integration Site 1 Homolog), is a GTPase implicated in cellular signaling pathways. It interacts with the inositol 1.4.5-triphosphate receptor (IP3R), a key regulator of calcium release from the endoplasmic reticulum, suggesting its role in modulating calcium homeostasis. IRAG2 is encoded by the MRVI1 gene and is structurally related to IRAG1. another IP3R-associated protein involved in nitric oxide/cGMP-dependent signaling. While IRAG1 is well-characterized in vascular smooth muscle contraction, IRAG2's precise functional mechanisms remain less understood, though it is hypothesized to influence phosphoinositide signaling and intracellular calcium dynamics.
Antibodies targeting IRAG2 are primarily used as research tools to investigate its expression, localization, and interaction partners. Studies suggest IRAG2 may contribute to pathological conditions, including cancer progression and cardiovascular diseases, due to its regulatory effects on cell proliferation and apoptosis. Commercial IRAG2 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding in elucidating its tissue-specific roles. Recent research also explores its potential as a biomarker or therapeutic target, though further validation is needed. The development of specific, high-affinity IRAG2 antibodies remains critical for advancing understanding of its physiological and pathological relevance.
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