| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PLCB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PLCB2抗体的参考文献示例(内容为模拟虚构，仅供参考)：
1. **《PLCB2在B细胞受体信号传导中的关键作用》**
- 作者：Wang, X. 等
- 摘要：本研究通过Western blot和免疫荧光技术，利用PLCB2特异性抗体证实了其在B细胞受体信号通路中的激活机制，揭示了PLCB2与下游钙离子信号的关系。
2. **《PLCB2缺陷小鼠血小板功能异常的表型分析》**
- 作者：Smith, J. 等
- 摘要：通过构建PLCB2基因敲除小鼠模型，结合抗体免疫组化分析，发现PLCB2缺失导致血小板活化障碍，影响凝血功能。
3. **《PLCB2在急性髓系白血病中的表达及临床意义》**
- 作者：Zhang, L. 等
- 摘要：采用PLCB2抗体对患者样本进行流式细胞术检测，发现PLCB2高表达与白血病耐药性相关，提示其作为潜在治疗靶点。
4. **《PLCB2在巨噬细胞炎症反应中的调控机制》**
- 作者：Brown, K. 等
- 摘要：研究通过抗体阻断实验及siRNA干扰，证明PLCB2通过调节NF-κB通路影响巨噬细胞炎症因子释放，为免疫疾病提供新见解。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed或Web of Science。)
The phospholipase C beta 2 (PLCB2) antibody is a tool used to detect and study the PLCB2 enzyme, a member of the phospholipase C (PLC) family involved in intracellular signaling. PLCB2 is activated by G protein-coupled receptors (GPCRs) and plays a critical role in hydrolyzing phosphatidylinositol 4.5-bisphosphate (PIP2) into secondary messengers inositol 1.4.5-trisphosphate (IP3) and diacylglycerol (DAG). These messengers regulate calcium release and protein kinase C activation, influencing processes like immune response, neurotransmission, and cell proliferation. PLCB2 is predominantly expressed in hematopoietic cells, including platelets, lymphocytes, and neutrophils, and is implicated in immune regulation and inflammatory pathways.
PLCB2 antibodies are essential for investigating the enzyme's expression, localization, and function in physiological and pathological contexts. They are utilized in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry to quantify PLCB2 levels in tissues or cell lines. Research involving PLCB2 antibodies has shed light on its role in immune disorders, cancer progression (e.g., leukemia), and platelet activation mechanisms. For instance, PLCB2 dysregulation has been linked to impaired immune cell signaling and thrombotic diseases. These antibodies also aid in exploring therapeutic targets, as modulating PLCB2 activity could influence downstream pathways in autoimmune diseases or malignancies. Validation of PLCB2 antibodies includes specificity checks via knockout controls and cross-reactivity assessments to ensure accurate experimental outcomes.
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