WB | 咨询技术 | Human,Mouse,Rat |
IF | 1/100-1/200 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Host/Isotype | Mouse IgG2b |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human STAT2 |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与STAT2抗体相关的研究文献及其摘要的简要列举:
1. **文献名称**: "STAT2 acts as a host range determinant for species-specific interferon signaling"
**作者**: Levy DE, et al.
**摘要**: 该研究揭示了STAT2在干扰素(IFN)信号通路中的物种特异性作用,利用STAT2抗体验证其在跨物种病毒防御中的关键功能,发现STAT2的结构差异决定了不同哺乳动物对病毒感染的敏感性。
2. **文献名称**: "Targeting STAT2 by the alphavirus nonstructural protein for inhibition of type I interferon responses"
**作者**: Ashour J, et al.
**摘要**: 通过STAT2抗体实验,该研究证明甲病毒非结构蛋白通过降解STAT2抑制I型干扰素抗病毒反应,揭示了病毒逃逸宿主免疫的机制,为抗病毒治疗提供潜在靶点。
3. **文献名称**: "STAT2 deficiency underlies a type I interferon-independent autoimmune phenotype in mice"
**作者**: Park C, et al.
**摘要**: 利用STAT2基因敲除小鼠和抗体检测,研究发现STAT2缺失可导致不依赖I型干扰素的自免疫表型,提示STAT2在调节自身免疫反应中的独特作用,为自身免疫疾病机制提供新见解。
4. **文献名称**: "The role of STAT2 in cancer immunology: A double-edged sword"
**作者**: Meinke A, et al.
**摘要**: 该综述通过分析STAT2抗体相关实验数据,总结STAT2在肿瘤微环境中的双重角色:既能增强抗病毒免疫,又可能促进肿瘤免疫逃逸,强调其在癌症免疫治疗中的复杂调控网络。
以上文献均通过STAT2抗体实验验证其在免疫信号、病毒学或肿瘤学中的功能,可作为相关领域研究的基础参考。
**Background of STAT2 Antibody**
STAT2 (Signal Transducer and Activator of Transcription 2) is a critical transcription factor involved in interferon (IFN)-mediated signaling pathways, particularly those activated by type I (IFN-α/β) and type III (IFN-λ) interferons. It plays a central role in innate immunity by regulating the expression of interferon-stimulated genes (ISGs) that mediate antiviral, antiproliferative, and immunomodulatory responses. Structurally, STAT2 contains an SH2 domain critical for phosphorylation-dependent activation and interaction with other signaling components. Upon IFN binding to receptors, STAT2 is tyrosine-phosphorylated by JAK kinases, enabling it to dimerize with STAT1 and form the IFN-stimulated gene factor 3 (ISGF3) complex alongside IRF9. This complex translocates to the nucleus to initiate ISG transcription.
STAT2 antibodies are essential tools for studying its expression, activation, and localization in cells or tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate STAT2’s role in viral infections, autoimmune diseases, and cancers. Dysregulation of STAT2 is linked to impaired immune responses and oncogenesis, making it a potential therapeutic target. Commercial STAT2 antibodies are typically validated for specificity across species (e.g., human, mouse) and applications, aiding research into IFN signaling mechanisms and related pathologies.
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