Mouse Monoclonal GIPC2 Antibody

The GIPC2 (GAIP Interacting Protein C-Terminus 2) antibody is a tool used to study the GIPC2 protein, part of the GIPC family involved in regulating cellular processes like signal transduction, vesicular trafficking, and receptor localization. GIPC2 contains a conserved PDZ domain, enabling interactions with C-terminal motifs of partner proteins, such as receptors and transporters. It plays roles in endocytic pathways, membrane protein stabilization, and intracellular signaling networks, including pathways linked to growth factors and tyrosine kinase receptors. Dysregulation of GIPC2 has been implicated in cancers, where it may act as an oncogene or tumor suppressor depending on context. For example, studies suggest its involvement in gastric, breast, and ovarian cancers, often correlating with disease progression. The GIPC2 antibody facilitates detection and analysis of GIPC2 expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to explore GIPC2's functional roles in normal physiology and disease, including its interactions with binding partners and potential as a therapeutic target. Its development underscores growing interest in PDZ domain-containing proteins as regulators of critical cellular functions and pathologies.