| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PLCB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是几篇关于PLCB2抗体的示例文献(注：以下内容为模拟示例，非真实文献，仅供格式参考)：
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1. **文献名称**：*PLCB2 modulates neutrophil chemotaxis through antibody-based targeting in inflammatory diseases*
**作者**：Zhang, L. et al.
**摘要**：本研究利用PLCB2特异性抗体，通过免疫荧光和流式细胞术分析中性粒细胞中PLCB2的表达水平，发现其通过调控钙离子信号通路影响细胞迁移，为炎症性疾病治疗提供新靶点。
2. **文献名称**：*Characterization of a novel monoclonal antibody against PLCβ2 for leukemia diagnostics*
**作者**：Tanaka, K. et al.
**摘要**：报道了一种高特异性抗PLCB2单克隆抗体的开发，通过免疫组化验证其在急性髓系白血病细胞中的高表达，提示其作为潜在生物标志物的价值。
3. **文献名称**：*PLCB2 deficiency in B cells revealed by antibody-mediated knockdown*
**作者**：Müller, R. et al.
**摘要**：采用PLCB2抗体进行功能阻断实验，证明PLCB2缺失会损害B细胞受体信号传导，导致抗体产生异常，揭示了其在适应性免疫中的关键作用。
4. **文献名称**：*Antibody-based profiling of PLCβ2 in solid tumors*
**作者**：Gupta, S. et al.
**摘要**：通过PLCB2抗体对多种癌症组织进行染色，发现其在乳腺癌和结直肠癌中显著高表达，提示其可能成为肿瘤微环境研究的工具分子。
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如需查找真实文献，建议通过PubMed或Google Scholar搜索关键词“PLCB2 antibody”或“Phospholipase C Beta 2 antibody”，并筛选近年的研究论文或综述。
The phospholipase C beta 2 (PLCB2) antibody is a critical tool for studying the PLCβ2 enzyme, a member of the phospholipase C family involved in intracellular signaling. PLCβ2 is activated by G protein-coupled receptors (GPCRs) and hydrolyzes phosphatidylinositol 4.5-bisphosphate (PIP2) into inositol 1.4.5-trisphosphate (IP3) and diacylglycerol (DAG), secondary messengers that regulate calcium release and protein kinase C activation. PLCB2 is predominantly expressed in hematopoietic cells, including platelets, neutrophils, and certain lymphocytes, where it mediates immune responses, inflammation, and cell proliferation.
PLCB2 antibodies are widely used in research to detect PLCβ2 expression and localization via techniques like Western blotting, immunohistochemistry, and flow cytometry. These antibodies help investigate PLCβ2's role in immune disorders, hematopoiesis, and cancers, as dysregulation of PLCβ2 signaling is linked to pathologies such as immune deficiencies, thrombocytopenia, and leukemia. Additionally, studies using PLCB2 antibodies have explored its interaction with signaling molecules like Gαq and Rac GTPases, providing insights into cross-talk between signaling pathways.
The development of PLCB2-specific antibodies has advanced diagnostic and therapeutic research, particularly in targeting GPCR-driven pathways. Their application continues to clarify PLCβ2's contribution to cellular physiology and disease mechanisms, aiding drug discovery and biomarker identification.
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