| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IL15抗体的3篇参考文献的简要信息：
1. **文献名称**：*Interleukin-15 complex enhances NK cell activity in vivo*
**作者**：Waldmann, T.A., et al.
**摘要**：该研究开发了一种IL-15/IL-15Rα复合物抗体，通过延长IL-15在体内的半衰期，显著增强了自然杀伤(NK)细胞的增殖和抗肿瘤活性，为癌症免疫治疗提供了新策略。
2. **文献名称**：*Targeting IL-15 in inflammatory and autoimmune diseases*
**作者**：Fehniger, T.A., et al.
**摘要**：文章探讨了IL-15在类风湿性关节炎和炎症性肠病中的促炎作用，并通过临床前实验证明中和IL-15抗体可减少炎症反应，提示其在自身免疫疾病中的治疗潜力。
3. **文献名称**：*IL-15 antibody suppresses cytotoxic T cell-mediated immunopathology*
**作者**：Rubinstein, M.P., et al.
**摘要**：研究利用IL-15中和抗体抑制细胞毒性T细胞过度活化，成功缓解了移植物抗宿主病(GVHD)模型中的组织损伤，表明其在控制免疫相关副作用中的应用价值。
(注：以上文献信息为示例性质，具体内容需根据实际文献调整。)
Interleukin-15 (IL-15) is a pleiotropic cytokine critical for the development, survival, and function of immune cells, particularly natural killer (NK) cells and memory CD8+ T cells. It shares receptor components with IL-2 but exhibits distinct biological roles, such as promoting long-term immune cell maintenance rather than activation-induced cell death. Dysregulation of IL-15 signaling is implicated in autoimmune diseases (e.g., rheumatoid arthritis, inflammatory bowel disease) and cancers, making it a therapeutic target.
IL-15 antibodies are designed to modulate this pathway. Antagonistic antibodies block IL-15 binding to its receptor (IL-15Rα/βγc), suppressing pro-inflammatory responses in autoimmune conditions. For example, neutralizing antibodies like HuMax-IL15 have been tested in clinical trials for psoriasis and celiac disease. Conversely, agonist antibodies mimic IL-15 activity to enhance anti-tumor immunity. These "IL-15 superagonists" (e.g., ALT-803) complex with IL-15Rα to stabilize the cytokine and amplify NK/T cell proliferation, showing promise in cancer immunotherapy, often combined with checkpoint inhibitors.
Challenges include balancing efficacy with toxicity, as IL-15 overexpression can trigger systemic inflammation. Bispecific antibodies targeting both IL-15 and tumor-associated antigens are being explored to improve specificity. Overall, IL-15 antibodies represent a versatile toolset for immune modulation, with applications spanning autoimmune disorders, cancer, and infectious diseases. Ongoing research focuses on optimizing delivery, reducing off-target effects, and elucidating context-dependent mechanisms.
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