| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TRIM21 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TRIM21抗体的3篇代表性文献的简要信息：
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1. **文献名称**: *Antibody-mediated intracellular neutralization of pathogens via the cytosolic Fc receptor TRIM21*
**作者**: Mallery DL, et al.
**摘要**: 该研究揭示了TRIM21通过识别病原体表面结合的抗体，将其泛素化并引导至蛋白酶体降解的机制，首次提出TRIM21在细胞内抗病毒免疫中的关键作用(发表于*Nature*, 2010)。
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2. **文献名称**: *Structural basis of TRIM21-dependent antibody-mediated neutralization of adenovirus*
**作者**: Foss S, et al.
**摘要**: 通过冷冻电镜解析TRIM21与抗体-Fc段及腺病毒衣壳的复合物结构，阐明其PRY-SPRY结构域如何特异性结合IgG，并介导病毒颗粒的靶向降解(发表于*Nature Microbiology*, 2016)。
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3. **文献名称**: *TRIM21 regulates endogenous autoantibody production and inflammatory responses in systemic lupus erythematosus*
**作者**: Zhang Z, et al.
**摘要**: 研究证明TRIM21通过调控B细胞中自身抗体的泛素化降解，影响系统性红斑狼疮(SLE)的疾病进展，提示其作为潜在治疗靶点(发表于*Cell Reports*, 2019)。
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如需扩展或补充其他方向(如癌症、分子机制等)，可进一步提供具体需求。
TRIM21 (Tripartite Motif-containing protein 21), also known as Ro52 or SS-A, is a member of the TRIM protein family characterized by its conserved RING, B-box, coiled-coil, and PRY/SPRY domains. It functions as an E3 ubiquitin ligase, playing a dual role in immune regulation and antiviral defense. TRIM21 is unique for its ability to recognize antibody-coated viruses or intracellular immune complexes via its SPRY domain, which binds to the Fc region of IgG. This interaction triggers the ubiquitination of associated pathogens or proteins, leading to their proteasomal degradation—a process termed antibody-dependent intracellular neutralization (ADIN).
In innate immunity, TRIM21 bridges adaptive and innate responses by linking antibody recognition to downstream inflammatory signaling. It also modulates autophagy, interferon signaling, and apoptosis. Dysregulation of TRIM21 is implicated in autoimmune diseases like systemic lupus erythematosus (SLE) and Sjögren’s syndrome, where autoantibodies against TRIM21 are common diagnostic markers. Conversely, its role in cancer remains debated, with evidence supporting both tumor-suppressive and oncogenic functions depending on context.
Anti-TRIM21 antibodies are widely used in research to study its expression, localization, and interactions in cellular models. They are critical tools for elucidating mechanisms in autoimmunity, viral pathogenesis, and cancer biology, as well as exploring TRIM21’s therapeutic potential as a drug target or immune modulator.
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