| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LAMA4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于LAMA4抗体的虚构参考文献示例，基于相关领域常见研究方向整理而成：
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1. **文献名称**: *LAMA4 Expression in Tumor Microenvironments Promotes Metastatic Invasion via Integrin Signaling*
**作者**: Chen, Y.; Yamamoto, H.; Park, J.
**摘要**: 本研究利用抗LAMA4抗体分析多种癌症模型，发现LAMA4在肿瘤细胞外基质中高表达，并通过整合素β1信号通路增强癌细胞的迁移和侵袭能力。抑制LAMA4可显著减少小鼠模型中肺转移灶的形成。
2. **文献名称**: *Anti-LAMA4 Autoantibodies as a Potential Biomarker for Autoimmune Vasculopathies*
**作者**: Müller, R.; Schmidt, T.; Eriksson, D.
**摘要**: 通过ELISA和免疫组化技术，研究者发现抗LAMA4自身抗体在系统性血管炎患者血清中特异性升高，提示LAMA4可能参与血管内皮损伤的病理过程，或成为此类疾病的诊断标志物。
3. **文献名称**: *Targeting LAMA4-Dependent Angiogenesis in Glioblastoma with Neutralizing Antibodies*
**作者**: Stupp, R.; Lee, S.W.; Jain, R.
**摘要**: 实验表明，胶质母细胞瘤微血管内皮细胞高表达LAMA4.使用特异性中和抗体阻断其功能后，肿瘤血管密度降低40%，小鼠生存期延长，证实LAMA4是抗血管生成治疗的潜在靶点。
4. **文献名称**: *LAMA4 Deficiency Alters Cardiac Fibrosis Pathways Revealed by Knockout Mouse Models*
**作者**: Zhou, L.; Hynes, R.O.; Zhang, P.
**摘要**: 通过构建LAMA4基因敲除小鼠，发现其心脏纤维化程度减轻，机制涉及TGF-β信号下调。抗LAMA4抗体染色进一步揭示其在心肌修复中的动态表达变化。
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*注：上述文献为模拟示例，实际研究中请通过PubMed或Web of Science等平台检索真实文献。*
The LAMA4 antibody targets laminin alpha-4 (LAMA4), a subunit of the extracellular matrix protein laminin-411 (α4β1γ1) and laminin-421 (α4β2γ1). LAMA4 is a key component of basement membranes, playing critical roles in cell adhesion, migration, and tissue organization. It is widely expressed in developing and adult tissues, including blood vessels, muscle, and nervous systems. LAMA4-containing laminins are involved in angiogenesis, wound healing, and maintaining vascular integrity, with emerging links to pathological conditions such as cancer metastasis, cardiovascular diseases, and fibrosis.
LAMA4 antibodies, typically monoclonal or polyclonal, are essential tools for studying the protein's expression, localization, and function. They are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate LAMA4 distribution in normal versus diseased tissues. Research highlights its dual role: promoting endothelial cell survival during vascular development while facilitating tumor progression by enhancing invasiveness and angiogenesis. Dysregulation of LAMA4 has been observed in cancers (e.g., breast, lung) and fibrotic disorders, making it a potential biomarker or therapeutic target.
Recent studies also explore LAMA4's interaction with integrin receptors (e.g., α6β1. αvβ3) and its role in modulating signaling pathways like PI3K/AKT and FAK. Despite progress, challenges remain in understanding tissue-specific isoforms and context-dependent functions. LAMA4 antibodies thus remain vital for dissecting its complex roles in health and disease.
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