| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human RGS18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于RGS18抗体的3篇参考文献示例(注：文献信息基于已有研究领域知识模拟，实际引用时请通过学术数据库验证准确性)：
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1. **文献名称**: *"RGS18 is a critical regulator of platelet activation and hemostasis"*
**作者**: Fukuhara S, et al.
**摘要**: 本研究阐明了RGS18在血小板信号传导中的调控作用，通过特异性抗体验证了RGS18在抑制Gαq信号通路中的功能，并证明其缺失会导致血小板过度活化和血栓形成倾向。
2. **文献名称**: *"Development and validation of a monoclonal antibody targeting RGS18 for immune cell analysis"*
**作者**: Li Y, et al.
**摘要**: 文章报道了一种针对RGS18蛋白的高特异性单克隆抗体的开发，该抗体通过Western blot和流式细胞术验证，可用于检测巨核细胞和血小板中的RGS18表达水平。
3. **文献名称**: *"RGS18 modulates B cell receptor signaling and autoimmune responses"*
**作者**: Yoo A, et al.
**摘要**: 研究利用RGS18抗体进行免疫沉淀和共聚焦显微成像，揭示了RGS18在B细胞受体信号负调控中的作用，及其在自身免疫疾病中的潜在治疗价值。
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如需获取具体文献，建议通过 **PubMed** 或 **Google Scholar** 检索关键词：
`RGS18 antibody`、`RGS18 platelet`、`RGS18 immune regulation`。
部分研究可能涉及抗体在疾病模型(如血栓、白血病)中的应用。
The Regulator of G-protein Signaling 18 (RGS18) is a member of the RGS protein family, which functions as GTPase-activating proteins (GAPs) to negatively regulate G-protein-coupled receptor (GPCR) signaling by accelerating GTP hydrolysis on Gα subunits. RGS18 is predominantly expressed in platelets, megakaryocytes, and certain immune cells, where it modulates signaling pathways critical for platelet activation, hemostasis, and inflammatory responses. Its role in attenuating Gαq and Gαi/o signaling makes it a key regulator of thrombotic and immune processes.
RGS18-specific antibodies are essential tools for studying its expression, localization, and functional interactions. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in investigations of RGS18's physiological and pathological roles. Research has linked RGS18 dysregulation to bleeding disorders, thrombocytopenia, and cancer metastasis, highlighting its potential as a therapeutic target or biomarker.
The development and validation of high-affinity RGS18 antibodies are crucial for elucidating its mechanisms in platelet signaling cascades, immune cell regulation, and disease progression. Such reagents support translational studies aiming to modulate RGS18 activity in thrombosis, inflammation, or oncology-related pathways, underscoring its growing relevance in biomedical research.
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