Mouse Monoclonal SERPINC1 Antibody

SERPINC1. also known as antithrombin III (ATIII), is a serine protease inhibitor critical for regulating blood coagulation. It inactivases thrombin, factor Xa, and other clotting factors by forming stable complexes, thereby preventing excessive clot formation. SERPINC1 deficiency, either inherited or acquired, is linked to thrombotic disorders like deep vein thrombosis (DVT) and pulmonary embolism. Antibodies targeting SERPINC1 are essential tools for studying its expression, structure-function relationships, and role in hemostasis. They are widely used in immunoassays (e.g., ELISA, Western blot) to quantify antithrombin levels in clinical diagnostics, particularly for identifying hereditary thrombophilia or monitoring conditions such as liver disease, nephrotic syndrome, or disseminated intravascular coagulation (DIC). Additionally, these antibodies aid in research on thrombosis mechanisms, drug development (e.g., recombinant antithrombin therapies), and quality control of plasma-derived antithrombin products. Specificity and validation of SERPINC1 antibodies are crucial, as cross-reactivity with other serpins may compromise experimental accuracy. Recent studies also explore their utility in understanding antithrombin’s non-hemostatic roles, including anti-inflammatory and anti-angiogenic effects.