| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgA |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human INHBA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于INHBA抗体的3篇参考文献及其摘要概括：
1. **"INHBA overexpression correlates with poor prognosis in gastric cancer and promotes tumor progression via TGF-β signaling"**
- **作者**: Zhang et al.
- **摘要**: 该研究通过免疫组化(使用INHBA特异性抗体)发现，INHBA在胃癌组织中高表达，且与患者预后不良相关。实验表明INHBA通过激活TGF-β信号通路促进肿瘤侵袭和转移。
2. **"Targeting INHBA in ovarian cancer: A therapeutic strategy supported by antibody-based detection"**
- **作者**: Smith et al.
- **摘要**: 研究利用INHBA抗体验证其在卵巢癌细胞系中的高表达，并开发了一种抗体靶向疗法，通过抑制INHBA减少肿瘤生长和化疗耐药性，提示其作为治疗靶点的潜力。
3. **"INHBA regulates skeletal muscle development and regeneration through myostatin signaling"**
- **作者**: Lee et al.
- **摘要**: 通过Western blot和免疫荧光(使用INHBA抗体)，研究发现INHBA在骨骼肌发育和再生中通过调控肌肉生长抑制素(myostatin)信号通路发挥作用，为肌肉疾病治疗提供新方向。
4. **"INHBA as a biomarker in reproductive disorders: Insights from immunohistochemical analysis"**
- **作者**: Brown et al.
- **摘要**: 利用INHBA抗体对多囊卵巢综合征(PCOS)患者的卵巢组织进行分析，发现INHBA表达异常与卵泡发育障碍相关，提示其可能成为生殖疾病的诊断标志物。
以上研究均通过INHBA抗体揭示了该蛋白在不同生理病理过程中的功能，涵盖癌症、肌肉发育及生殖健康等领域。
**Background of INHBA Antibody**
INHBA (Inhibin Subunit Beta A) is a key gene encoding the beta-A subunit of activins and inhibins, which belong to the transforming growth factor-beta (TGF-β) superfamily. Activins, formed by dimerization of INHBA with other subunits (e.g., INHBB), regulate diverse biological processes, including cell proliferation, differentiation, apoptosis, immune response, and reproductive functions. INHBA overexpression is implicated in pathological conditions such as cancer progression, fibrosis, and inflammatory diseases, making it a biomarker and therapeutic target.
INHBA antibodies are essential tools for detecting and quantifying INHBA protein levels in research. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study INHBA expression patterns in tissues or cell lines, aiding in understanding its role in development and disease. Specificity and validation (e.g., knockout controls) are critical to ensure accurate detection, given structural similarities among TGF-β family members.
Clinically, INHBA antibodies contribute to biomarker studies in cancers (e.g., colorectal, gastric) and fibrotic disorders. Therapeutic antibodies targeting INHBA/activin signaling are also under investigation for conditions like muscle wasting and cancer cachexia. Researchers must select antibodies validated for their intended applications, considering factors like host species, clonality, and epitope regions. Quality control, including batch consistency and cross-reactivity checks, ensures reliable experimental outcomes.
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