| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant human IgE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3条关于Human IgE抗体的参考文献概览：
1. **标题**：*The structure and function of IgE*
**作者**：Metzger, H.
**摘要**：该文献解析了IgE抗体的分子结构，重点阐述其Fc段与高亲和力受体FcεRI的结合机制，并探讨其在过敏反应中的信号传导作用(发表于《Annual Review of Immunology》)。
2. **标题**：*IgE in allergy and asthma today*
**作者**：Sutton, B.J. & Gould, H.J.
**摘要**：综述了IgE介导的过敏性疾病(如哮喘、荨麻疹)的病理机制，强调IgE与肥大细胞、嗜碱性粒细胞的相互作用及抗IgE疗法(如奥马珠单抗)的临床进展(发表于《Nature Reviews Immunology》)。
3. **标题**：*Anti-IgE therapy: clinical utility and mechanistic insights*
**作者**：Chang, T.W. et al.
**摘要**：分析抗IgE单克隆抗体(如奥马珠单抗)的研发与应用，揭示其通过阻断IgE与受体结合来减轻过敏症状的分子机制，并总结临床试验数据(发表于《Journal of Allergy and Clinical Immunology》)。
如需更具体领域(如寄生虫免疫、IgE检测技术)的文献，可补充说明。
Human immunoglobulin E (IgE) is a key antibody isotype involved in type I hypersensitivity reactions and allergic responses. Discovered in 1967. IgE has a characteristic structure comprising two heavy chains (ε-chains) and two light chains, with a high-affinity Fc region binding to FcεRI receptors on mast cells and basophils. Unlike other immunoglobulins, IgE exists at very low concentrations in serum (nanograms per milliliter) under normal conditions but increases dramatically during allergic disorders or parasitic infections.
Its primary biological role involves host defense against helminths and certain protozoan parasites by triggering mast cell degranulation and eosinophil activation. However, in allergic individuals, IgE mistakenly recognizes harmless antigens (allergens) like pollen or food proteins, leading to cross-linking of FcεRI-bound IgE molecules. This activates effector cells to release histamine, leukotrienes, and cytokines, causing immediate symptoms (itching, bronchoconstriction) and late-phase inflammation.
Clinically, serum IgE levels are measured to assess allergic conditions (asthma, atopic dermatitis) and parasitic infections. Allergen-specific IgE testing forms the basis of diagnostic tools like RAST tests. Therapeutic strategies targeting IgE include anti-IgE monoclonal antibodies (e.g., omalizumab) that block FcεRI binding, as well as allergen immunotherapy to modulate IgE production. Recent research explores IgE's role in cancer immunosurveillance and autoimmune diseases, expanding its clinical significance beyond classical allergy paradigms.
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