| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Rat IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | Purified recombinant fragment of mouse Gata3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于GATA3抗体的代表性文献(简略版)：
1. **文献名称**: *GATA3: a multispecific but potentially useful marker in surgical pathology*
**作者**: Miettinen M, McCue PA.
**摘要**: 总结了GATA3抗体在多种肿瘤(如乳腺癌、尿路上皮癌)中的诊断价值，强调其敏感性和特异性，并讨论其在鉴别转移性肿瘤中的应用。
2. **文献名称**: *GATA3 immunohistochemical expression in salivary gland and urothelial carcinoma*
**作者**: Higgins K, et al.
**摘要**: 通过免疫组化分析，证实GATA3抗体在唾液腺癌和尿路上皮癌中的高表达，提出其作为鉴别诊断标记物的实用性。
3. **文献名称**: *GATA3 expression in T-cell lymphomas: a review*
**作者**: Chen BJ, et al.
**摘要**: 探讨GATA3抗体在T细胞淋巴瘤亚型中的表达差异，发现其与特定临床亚型(如血管免疫母细胞淋巴瘤)的相关性。
注：以上内容为示例，具体文献需根据实际数据库检索。建议通过PubMed或Google Scholar搜索关键词“GATA3 antibody”或“GATA3 immunohistochemistry”获取最新研究。
GATA3 antibody is a valuable diagnostic tool used in immunohistochemistry to detect the presence of GATA3 protein, a transcription factor critical for cellular differentiation and tissue development. The GATA3 gene, located on chromosome 10p15. encodes a member of the GATA family of zinc-finger DNA-binding proteins, which regulate gene expression by binding to the consensus sequence (A/T)GATA(A/G). GATA3 plays a pivotal role in the development and function of multiple tissues, including the mammary glands, kidneys, parathyroid glands, and immune system, particularly in T-cell differentiation and Th2 immune responses.
In diagnostic pathology, GATA3 is widely recognized as a sensitive and specific marker for breast carcinomas, especially estrogen receptor (ER)-positive luminal subtypes, and urothelial (transitional cell) carcinomas. Its expression is also observed in other tumors, such as cutaneous basal cell carcinoma, parathyroid adenomas, and a subset of renal cell carcinomas. In breast cancer, GATA3 expression correlates with ER and progesterone receptor (PR) positivity, aiding in tumor classification and prognosis. Conversely, loss of GATA3 is associated with aggressive tumor behavior and poorer outcomes.
GATA3 antibodies are essential for distinguishing primary tumor origins in metastatic cancers and identifying T-cell lymphomas, where GATA3 overexpression may indicate a Th2-polarized microenvironment. Its utility in both diagnostic and research settings underscores its importance in understanding tumor biology and guiding therapeutic strategies.
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