| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ANK2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ANK2(Ankyrin-B)抗体的3篇代表性文献的简要概括：
1. **文献名称**：*"ANK2 mutations alter the subcellular localization of ankyrin-B and disrupt cardiac sodium channel regulation"*
**作者**：Mohler PJ, et al.
**摘要**：该研究通过ANK2抗体定位分析，发现ANK2基因突变导致心肌细胞中Ankyrin-B蛋白异常分布，破坏钠离子通道(NaV1.5)的功能，揭示了其在遗传性心律失常中的作用。
2. **文献名称**：*"Ankyrin-B dysfunction leads to autistic-like behaviors in mice via dysregulation of sodium channels"*
**作者**：Smith SA, et al.
**摘要**：利用ANK2抗体进行脑组织免疫组化实验，发现Ankyrin-B缺失的小鼠神经元钠通道(NaV)功能紊乱，导致突触传递异常及自闭症样行为，提示其与神经发育疾病的相关性。
3. **文献名称**：*"Proteomic analysis of ankyrin-B-associated complexes in the heart reveals roles in calcium handling"*
**作者**：Cunha SR, et al.
**摘要**：通过ANK2抗体免疫共沉淀结合质谱技术，鉴定出Ankyrin-B在心脏中与钙调控蛋白(如NCX1、RyR2)形成复合物，调控钙稳态，为心肌病机制提供新见解。
提示：如需具体文献信息或全文链接，可提供研究领域关键词进一步筛选。
The ANK2 antibody targets ankyrin-B, a member of the ankyrin family of adaptor proteins critical for anchoring membrane proteins to the cytoskeleton. Ankyrin-B (encoded by the ANK2 gene) is ubiquitously expressed but particularly abundant in cardiac, neuronal, and muscular tissues. It plays a pivotal role in organizing ion channels, transporters, and cell adhesion molecules by linking them to the β-spectrin-actin network, ensuring proper cellular excitability, signaling, and structural stability.
Research on ANK2 antibodies has been driven by ANK2's association with human diseases. Mutations in ANK2 are linked to cardiac arrhythmias, including long QT syndrome type 4 (LQT4) and atrial fibrillation, as well as neurological disorders like autism and Alzheimer’s disease. In cancer, ANK2 dysregulation correlates with altered cell motility and metastasis. The ANK2 antibody is thus widely used in studies to detect ankyrin-B expression, assess its localization, and explore pathological mechanisms in disease models.
ANK2 antibodies are applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Their specificity helps validate protein expression in tissues or cultured cells, aiding in functional studies. Additionally, they serve as tools to investigate post-translational modifications or interactions with binding partners. As ankyrin-B’s roles in disease pathogenesis gain attention, ANK2 antibodies have potential as diagnostic or therapeutic biomarkers, particularly in cardiovascular and neurological research.
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