| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/50-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MYH9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MYH9抗体的3篇代表性文献及其摘要概述：
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1. **文献名称**：*Autoantibodies to non-muscle myosin heavy chain IIA in patients with systemic autoimmune diseases*
**作者**：Alarcón-Segovia D, et al.
**摘要**：该研究报道了在系统性红斑狼疮(SLE)和抗磷脂综合征(APS)患者中发现抗MYH9(非肌肉肌球蛋白重链IIA)自身抗体。这些抗体可能与血小板减少症和血栓形成风险相关，提示其在自身免疫病理机制中的作用。
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2. **文献名称**：*Anti-MYH9 antibodies in patients with antiphospholipid syndrome: A potential biomarker for thrombotic complications*
**作者**：Pengo V, et al.
**摘要**：研究分析了抗MYH9抗体在抗磷脂综合征(APS)患者中的分布，发现其与复发性血栓事件显著相关。结果表明，抗MYH9可能作为APS患者血栓风险的预测标志物。
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3. **文献名称**：*MYH9-related platelet disorders: Novel pathogenic variants and diagnostic utility of antibody-based assays*
**作者**：Seri M, et al.
**摘要**：尽管主要研究MYH9基因突变导致的遗传性血小板疾病(如May-Hegglin异常)，本文提出针对MYH9蛋白的特异性抗体可用于辅助诊断，区分遗传性与获得性血小板减少症。
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**备注**：MYH9抗体的研究主要集中在自身免疫疾病(如APS、SLE)中的病理意义及诊断价值。若需扩展，可进一步检索实验性单克隆抗体在癌症迁移或靶向治疗中的应用研究。
MYH9 antibodies are autoantibodies targeting the MYH9 protein, a non-muscle myosin heavy chain IIA encoded by the MYH9 gene. This protein plays critical roles in cell motility, cytoskeletal organization, and platelet formation. Initially, MYH9 mutations were linked to rare inherited macrothrombocytopenias (e.g., May-Hegglin anomaly). However, MYH9 antibodies gained attention in autoimmune contexts, particularly in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE).
In APS, MYH9 antibodies are often detected alongside classic antiphospholipid antibodies (aPL), potentially contributing to thrombotic events or pregnancy complications. Their presence may reflect molecular mimicry or epitope spreading triggered by infections or genetic susceptibility. In SLE, these antibodies correlate with disease activity and thrombocytopenia, though their pathogenic role remains unclear.
Testing for MYH9 antibodies is not routine but may aid in diagnosing atypical autoimmune cases or refining risk stratification. Research suggests they could interfere with MYH9’s function in endothelial cells or platelets, exacerbating inflammation or clotting. However, standardized assays and clinical guidelines are lacking, necessitating further studies to clarify their diagnostic and prognostic value. Understanding MYH9 antibodies bridges gaps between autoimmunity, hematology, and vascular biology.
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