| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human METRNL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4条关于METRNL(Meteorin-like protein)抗体的模拟参考文献示例(内容为虚构，仅用于演示格式)：
1. **文献名称**: "METRNL Antibody-Based Detection of Serum Protein Levels in Metabolic Syndrome"
**作者**: Jung, T. S. et al.
**摘要**: 研究开发了一种高特异性METRNL多克隆抗体，用于ELISA检测人类血清中的METRNL水平，发现其在肥胖和胰岛素抵抗患者中显著升高，提示其作为代谢疾病生物标志物的潜力。
2. **文献名称**: "Neutralizing METRNL Antibody Attenuates Skeletal Muscle Regeneration in Mice"
**作者**: Lee, S. J. et al.
**摘要**: 通过构建抗METRNL的单克隆抗体，研究证明阻断METRNL信号会抑制小鼠肌肉损伤后的再生过程，表明METRNL在肌肉修复中具有关键作用。
3. **文献名称**: "METRNL-Specific Antibody Therapy Reduces Colitis-Associated Inflammation"
**作者**: Zhang, Y. et al.
**摘要**: 在实验性结肠炎模型中，使用人源化抗METRNL抗体靶向抑制其活性，显著降低了肠道促炎因子(如IL-6和TNF-α)的表达，提示其治疗炎症性肠病的可能性。
4. **文献名称**: "METRNL Antibody Reveals Tissue-Specific Expression Patterns in Adipose Tissue"
**作者**: Wang, X. et al.
**摘要**: 利用免疫组化及Western blot技术，通过特异性METRNL抗体揭示了其在白色脂肪组织中的高表达，并证实寒冷暴露通过METRNL调控产热相关基因。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“METRNL antibody”或“Meteorin-like protein therapeutic”。
METRNL (Meteorin-like), also known as subfatin or Cometin, is a secreted protein initially identified for its role in metabolic regulation and immune modulation. It shares structural homology with Meteorin and is expressed in adipose tissue, skeletal muscle, and immune cells, particularly macrophages. METRNL is implicated in energy homeostasis, insulin sensitivity, and inflammation, with studies linking it to brown adipose tissue activation, white adipose browning, and glucose metabolism. It interacts with receptors such as IL-41Ra (Interleukin-41 receptor alpha) and mediates anti-inflammatory responses by polarizing macrophages toward an M2 phenotype.
METRNL antibodies are research tools developed to detect and quantify METRNL protein levels in biological samples. These antibodies enable studies on METRNL's tissue distribution, secretion dynamics, and molecular mechanisms in metabolic diseases (e.g., obesity, diabetes), autoimmune disorders, and tissue repair. Commercial METRNL antibodies are typically validated for applications like Western blotting, immunohistochemistry, and ELISA. Recent research highlights its therapeutic potential, driving demand for high-specificity antibodies to explore METRNL as a biomarker or therapeutic target. Challenges include ensuring cross-reactivity across species and minimizing nonspecific binding due to structural similarities within the Meteorin family.
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