Mouse Monoclonal STEAP4 Antibody

The STEAP4 (Six-transmembrane epithelial antigen of the prostate 4) antibody is a tool used to study the STEAP4 protein, a member of the STEAP family involved in metal ion transport and redox processes. STEAP4. encoded by the *STEAP4* gene, is a transmembrane protein with six domains, primarily expressed in adipose tissue, prostate, and immune cells. It plays roles in cellular iron and copper metabolism, insulin signaling, and inflammatory responses. Research links STEAP4 to metabolic disorders like obesity, type 2 diabetes, and metabolic syndrome due to its regulation of adipocyte function and insulin sensitivity. It also modulates inflammatory pathways, influencing cytokines such as TNF-α and IL-6. In cancer biology, STEAP4 is implicated in prostate and other cancers, though its mechanisms remain unclear. Antibodies targeting STEAP4 enable detection of its expression, localization, and interactions in tissues or cell lines, aiding studies on metabolic diseases, cancer progression, and therapeutic targeting. Commercial STEAP4 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and flow cytometry, supporting both basic research and clinical investigations into its pathophysiological roles.