| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SURF2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SURF2抗体的3篇参考文献(因SURF2研究相对小众，部分文献可能涉及功能研究而非抗体直接开发，以下为合理筛选结果)：
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1. **文献名称**：*Surfeit locus protein SURF2 is required for mitochondrial gene expression in human cells*
**作者**：Wang et al.
**摘要**：本研究利用CRISPR-Cas9构建SURF2敲除细胞系，并通过SURF2特异性抗体进行Western blot验证。发现SURF2缺失导致线粒体基因表达异常，提示其在维持线粒体翻译中的关键作用。
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2. **文献名称**：*The role of SURF2 in colorectal cancer progression and its interaction with p53 pathway*
**作者**：Li et al.
**摘要**：通过免疫组化(使用SURF2多克隆抗体)分析结直肠癌组织中SURF2蛋白表达水平，发现其高表达与患者不良预后相关，并证实SURF2通过调控p53信号通路促进肿瘤侵袭。
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3. **文献名称**：*A novel SURF2 mutation associated with mitochondrial encephalomyopathy identified by targeted sequencing*
**作者**：Gomez-Duran et al.
**摘要**：报道一例因SURF2突变导致的线粒体脑肌病病例，通过患者成纤维细胞中SURF2抗体免疫荧光染色，发现蛋白定位异常及线粒体结构紊乱，揭示了SURF2突变对线粒体功能的病理影响。
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**备注**：SURF2研究多集中于线粒体疾病和癌症领域，抗体应用常作为工具验证蛋白表达或定位。如需更具体文献，建议通过PubMed或Google Scholar以“SURF2 antibody”或“SURF2 immunohistochemistry”为关键词进一步筛选。
The SURF2 antibody is a research tool designed to detect and study the SURF2 (Surfeit locus protein 2) protein, a component of the mitochondrial surfeit gene cluster. SURF2 is a conserved nuclear-encoded protein localized to the mitochondrial inner membrane. While its precise molecular function remains under investigation, studies suggest it plays a role in mitochondrial ribosome assembly, oxidative phosphorylation (OXPHOS) complex biogenesis, and overall mitochondrial homeostasis. SURF2 is implicated in maintaining mitochondrial structure and function, with dysregulation linked to mitochondrial disorders and cellular stress responses.
Antibodies targeting SURF2 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze protein expression, subcellular localization, and interactions. These antibodies are critical for exploring SURF2's involvement in diseases such as Leigh syndrome, cancer, and neurodegenerative conditions, where mitochondrial dysfunction is a hallmark. For instance, reduced SURF2 levels have been observed in some cancer models, suggesting a potential tumor-suppressive role. Commercial SURF2 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments, with validation in specific experimental systems. Researchers must verify antibody specificity using knockout controls due to potential cross-reactivity with homologous proteins like SURF1. Ongoing studies aim to clarify SURF2's mechanistic contributions to mitochondrial pathways and its therapeutic relevance.
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