Mouse Monoclonal UPB1 Antibody

The UPB1 antibody targets β-ureidopropionase 1 (UPB1), a key enzyme in the pyrimidine degradation pathway responsible for catalyzing the hydrolysis of β-alanine and β-aminoisobutyric acid. UPB1 plays a critical role in maintaining cellular homeostasis by regulating the metabolism of pyrimidine-derived intermediates. Dysregulation of UPB1 has been implicated in metabolic disorders, neurological conditions, and cancers, making it a subject of interest in biomedical research. The UPB1 antibody is widely utilized to investigate the enzyme's expression patterns, subcellular localization, and functional roles in both normal and diseased tissues. In diagnostic and experimental settings, it is employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess UPB1 levels in various biological samples. Studies have linked altered UPB1 activity to β-alanine-associated metabolic deficiencies and tumor progression, particularly in colorectal and hepatocellular carcinomas. The antibody's specificity for UPB1 across species, including human, mouse, and rat models, enhances its utility in comparative studies. Ongoing research aims to clarify UPB1's mechanistic contributions to disease pathways and its potential as a therapeutic target or biomarker.