| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human NPTXR |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与NPTXR抗体相关的文献摘要示例(注：文献为虚拟示例，实际文献需通过学术数据库检索)：
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1. **文献名称**: "NPTXR Antibody-Based Detection of Synaptic Dysfunction in Alzheimer's Disease"
**作者**: Smith A, et al.
**摘要**: 本研究利用NPTXR抗体检测阿尔茨海默病模型小鼠脑组织中的突触前蛋白表达水平，发现NPTXR表达显著降低与认知衰退相关，提示其作为神经退行性疾病生物标志物的潜力。
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2. **文献名称**: "NPTXR Modulates Excitatory Synapse Formation in Cortical Neurons"
**作者**: Tanaka K, et al.
**摘要**: 通过NPTXR抗体免疫染色结合CRISPR敲除技术，发现NPTXR通过调控AMPA受体聚集影响皮质神经元突触可塑性，揭示其在神经发育中的关键作用。
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3. **文献名称**: "Autoantibodies Against NPTXR in Paraneoplastic Neurological Syndromes"
**作者**: Lee S, et al.
**摘要**: 报道在副肿瘤性神经系统综合征患者血清中发现抗NPTXR自身抗体，其滴度与疾病严重程度相关，提示NPTXR可能成为自身免疫性神经疾病的诊断靶点。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“NPTXR antibody”或“Neuronal pentraxin receptor”，并筛选涉及抗体应用、疾病机制或分子功能的研究。
The neuronal pentraxin receptor (NPTXR) is a member of the neuronal pentraxin family, which includes secreted glycoproteins like NPTX1 and NPTX2. These proteins are implicated in synaptic plasticity, neurotransmitter release, and the remodeling of excitatory neural circuits. NPTXR is a transmembrane protein containing a pentraxin domain and a unique transmembrane region, distinguishing it from its secreted counterparts. It interacts with postsynaptic neuronal pentraxins (e.g., NPTX1/NPTX2) to regulate AMPA receptor clustering, thereby stabilizing synaptic connections and modulating long-term synaptic strength.
NPTXR is predominantly expressed in the central nervous system, particularly in regions associated with learning and memory, such as the hippocampus. Dysregulation of NPTXR has been linked to neurological disorders, including Alzheimer’s disease, schizophrenia, and autism spectrum disorders, where synaptic dysfunction is a hallmark. Reduced NPTXR levels, for instance, correlate with synaptic loss in Alzheimer’s models.
Antibodies targeting NPTXR are essential tools for studying its expression, localization, and interactions in neural tissues. They enable techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore its role in synaptic maintenance and disease mechanisms. Such research may reveal NPTXR as a potential biomarker or therapeutic target for neurodegenerative and neuropsychiatric conditions.
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