| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human DEFA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于DEFA1抗体的3篇参考文献示例(文献信息为模拟内容，仅供参考)：
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1. **文献名称**: *"Human neutrophil defensin 1 (DEFA1) as a novel biomarker for inflammatory bowel disease"*
**作者**: Smith A, et al.
**摘要**: 研究通过抗DEFA1抗体检测发现，DEFA1蛋白在炎症性肠病患者肠道组织中的表达显著升高，提示其可能参与黏膜免疫应答及炎症病理过程，可作为潜在生物标志物。
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2. **文献名称**: *"Antibody-based detection of DEFA1 in sepsis: correlation with disease severity"*
**作者**: Chen L, et al.
**摘要**: 利用特异性DEFA1抗体进行血清学分析，发现脓毒症患者血浆DEFA1水平与器官衰竭程度正相关，表明其可能作为脓毒症严重程度的预测指标。
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3. **文献名称**: *"DEFA1 antibody reveals altered defensin expression in autoimmune arthritis"*
**作者**: Tanaka K, et al.
**摘要**: 通过免疫组化及抗DEFA1抗体标记，发现类风湿性关节炎患者的滑膜组织中DEFA1阳性中性粒细胞浸润增加，提示其在关节局部免疫反应中起关键作用。
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**备注**：以上文献为示例，实际研究中建议通过PubMed或Google Scholar检索关键词(如“DEFA1 antibody”、“DEFA1 defensin”)获取真实文献。
The DEFA1 antibody targets human alpha-defensin 1 (DEFA1), a small cationic antimicrobial peptide primarily produced by neutrophils. DEFA1 belongs to the α-defensin family, which plays critical roles in innate immunity by directly killing pathogens (e.g., bacteria, viruses, fungi) and modulating immune responses. These peptides are stored in neutrophil granules and released during infection or inflammation. DEFA1. encoded by the *DEFA1* gene located on chromosome 8p23.1. forms pores in microbial membranes, disrupting their integrity. It also acts as a chemoattractant for immune cells and enhances phagocytosis.
DEFA1 antibodies are essential tools in biomedical research and diagnostics. They enable the detection of DEFA1 in tissues or bodily fluids (e.g., saliva, plasma) using techniques like immunohistochemistry (IHC), Western blotting, or ELISA. Such studies help investigate DEFA1’s role in diseases, including infections, inflammatory disorders (e.g., Crohn’s disease), and cancers. Elevated DEFA1 levels are linked to chronic inflammation, while deficiencies may correlate with susceptibility to infections. Commercially available DEFA1 antibodies are typically monoclonal or polyclonal, validated for specificity in human samples. Understanding DEFA1 dynamics via antibody-based assays contributes to therapeutic development, such as designing defensin-inspired antimicrobial agents or biomarkers for disease monitoring.
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